Many traditional bio-processes are operated in semi-batch mode, in which, a feed stream containing substrate and or nutrients is fed into the reactor during the course of the reaction. One key advantage of a semi-batch operation is that regulation of the substrate concentration has been found to be effective in mitigating the effects of substrate inhibition. Using enzymatic biodiesel production as a case study, the volumetric productivity of the reactor is increased while minimizing inactivation of the enzyme due to the alcohol. This is done by using a simple optimization routine where the substrate (both the vegetable oil and alcohol) feed rate/concentration is manipulated simultaneously. The results of the simulation were tested in the laboratory and are sufficiently positive to suggest the implementation of a feeding strategy for large scale enzymatic biodiesel production.
|Publication status||Published - 2013|
|Event||18th Nordic Process Control Workshop - University of Oulu, Oulu, Finland|
Duration: 22 Aug 2013 → 23 Aug 2013
|Conference||18th Nordic Process Control Workshop|
|Location||University of Oulu|
|Period||22/08/2013 → 23/08/2013|