Optimization of Substrate Feeding for Enzymatic Biodiesel Production

Jason Anthony Price, Jakob Kjøbsted Huusom, Mathias Nordblad, John Woodley

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Many traditional bio-processes are operated in semi-batch mode, in which, a feed stream containing substrate and or nutrients is fed into the reactor during the course of the reaction. One key advantage of a semi-batch operation is that regulation of the substrate concentration has been found to be effective in mitigating the effects of substrate inhibition. Using enzymatic biodiesel production as a case study, the volumetric productivity of the reactor is increased while minimizing inactivation of the enzyme due to the alcohol. This is done by using a simple optimization routine where the substrate (both the vegetable oil and alcohol) feed rate/concentration is manipulated simultaneously. The results of the simulation were tested in the laboratory and are sufficiently positive to suggest the implementation of a feeding strategy for large scale enzymatic biodiesel production
Original languageEnglish
Title of host publicationProceedings of the 18th Nordic Process Control Workshop (NPCW18)
Number of pages1
Publication date2013
Publication statusPublished - 2013
Event18th Nordic Process Control Workshop - University of Oulu, Oulu, Finland
Duration: 22 Aug 201323 Aug 2013


Conference18th Nordic Process Control Workshop
LocationUniversity of Oulu
Internet address


  • Biodiesel
  • Enzymatic
  • Transesterification
  • Modelling and Simulation
  • Process control

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