Abstract
This paper presents a multi-level optimization strategy to obtain optimum operating conditions (four flowrates and cycle time) of nonlinear simulated moving bed chromatography. The multi-level optimization procedure (MLOP) approaches systematically from initialization to optimization with two objective functions (productivity and desorbent consumption), employing the standing wave analysis, the true moving bed (TMB) model and the simulated moving bed (SMB) model. The procedure is constructed on a non-worse solution property advancing level by level and its solution does not mean a global optimum. That is, the lower desorbent consumption under the higher productivity is successively obtained on the basis of the SMB model, as the two SMB-model optimizations are repeated using a standard SQP (successive quadratic programming) algorithm. This approach takes advantage of the TMB model and surmounts shortcomings of the TMB model in the general case of nonlinear adsorption isotherm using the SMB model.
| Original language | English |
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| Title of host publication | European Symposium on Computer Aided Process Engineering - 14 |
| Publisher | Elsevier |
| Publication date | 2004 |
| Pages | 1087-1092 |
| ISBN (Print) | 0-444-51694-8, 978-0-444-51694-7 |
| DOIs | |
| Publication status | Published - 2004 |
| Event | 14th European Symposium on Computer Aided Process Engineering - Lisbon, Portugal Duration: 16 May 2004 → 19 May 2004 Conference number: 14 http://www.deb.uminho.pt/escape14/ |
Conference
| Conference | 14th European Symposium on Computer Aided Process Engineering |
|---|---|
| Number | 14 |
| Country/Territory | Portugal |
| City | Lisbon |
| Period | 16/05/2004 → 19/05/2004 |
| Internet address |
| Series | Computer Aided Chemical Engineering |
|---|---|
| Number | C |
| Volume | 18 |
| ISSN | 1570-7946 |
Keywords
- Simulated moving bed (SMB) chromatography
- Simulation
- Multi-level optimization procedure (MLOP)
- Productivity
- Desorbent consumption