Optimal diameter reduction ratio of acinar airways in human lungs

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review



  • Author: Park, Keunhwan

    Biophysics and Fluids, Department of Physics, Technical University of Denmark, Denmark

  • Author: Jung, Yeonsu

    Seoul National University

  • Author: Son, Taeho

    Seoul National University

  • Author: Cho, Young-Jae

    Seoul National University Bundang Hospital, Korea, Democratic People's Republic of

  • Author: Jeon, Noo Li

    Seoul National University

  • Author: Kim, Wonjung

    Sogang University

  • Author: Kim, Ho Young

    Seoul National University

View graph of relations

In the airway network of a human lung, the airway diameter gradually decreases through multiple branching. The diameter reduction ratio of the conducting airways that transport gases without gas exchange is 0.79, but this reduction ratio changes to 0.94 in acinar airways beyond transitional bronchioles. While the reduction in the conducting airways was previously rationalized on the basis of Murray’s law, our understanding of the design principle behind the acinar airways has been far from clear. Here we elucidate that the change in gas transfer mode is responsible for the transition in the diameter reduction ratio. The oxygen transfer rate per unit surface area is maximized at the observed geometry of acinar airways, which suggests the minimum cost for the construction and maintenance of the acinar airways. The results revitalize and extend the framework of Murray’s law over an entire human lung.

Original languageEnglish
Article numbere0204191
Issue number1
Number of pages10
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

Download statistics

No data available

ID: 167471275