Optics miniaturization strategy for demanding Raman spectroscopy applications

Oleksii Ilchenko*, Yurii Pilhun, Andrii Kutsyk, Denys Slobodianiuk, Yaman Goksel, Elodie Dumont, Lukas Vaut, Chiara Mazzoni, Lidia Morelli, Sofus Boisen, Konstantinos Stergiou, Yaroslav Aulin, Tomas Rindzevicius, Thomas Emil Andersen, Mikael Lassen, Hemanshu Mundhada, Christian Bille Jendresen, Peter Alshede Philipsen, Merete Hædersdal, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Raman spectroscopy provides non-destructive, label-free quantitative studies of chemical compositions at the microscale as used on NASA's Perseverance rover on Mars. Such capabilities come at the cost of high requirements for instrumentation. Here we present a centimeter-scale miniaturization of a Raman spectrometer using cheap non-stabilized laser diodes, densely packed optics, and non-cooled small sensors. The performance is comparable with expensive bulky research-grade Raman systems. It has excellent sensitivity, low power consumption, perfect wavenumber, intensity calibration, and 7 cm-1 resolution within the 400-4000 cm-1 range using a built-in reference. High performance and versatility are demonstrated in use cases including quantification of methanol in beverages, in-vivo Raman measurements of human skin, fermentation monitoring, chemical Raman mapping at sub-micrometer resolution, quantitative SERS mapping of the anti-cancer drug methotrexate and in-vitro bacteria identification. We foresee that the miniaturization will allow realization of super-compact Raman spectrometers for integration in smartphones and medical devices, democratizing Raman technology.
Original languageEnglish
Article number3049
JournalNature Communications
Volume15
Issue number1
Number of pages14
ISSN2041-1723
DOIs
Publication statusPublished - 2024

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