Optical radiomic signatures derived from OCT images to improve identification of melanoma

Zahra Turani, Emad Fatemizadeh, Tatiana Blumetti, Steven Daveluy, Ana Flavia Moraes, Wei Chen, Darius Mehregan, Peter E. Andersen, Mohammadreza Nasiriavanaki

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Abstract

Malignant melanoma is by far the most dangerous type of skin cancer. Currently, the gold standard to diagnose melanoma in the clinic is excisional biopsy and histopathologic analysis. Approximately 15-30 benign lesions are biopsied to diagnose each melanoma. Additionally, biopsies are invasive and result in pain, anxiety, scarring and disfigurement of patients, and they can be a financial burden to the health care system. Among several imaging techniques developed to enhance melanoma diagnosis, optical coherence tomography (OCT) with its high-resolution and intermediate penetration depth can potentially provide required diagnostic information, noninvasively. We propose an image analysis algorithm, ‘optical properties extraction (OPE)’ that drastically improves the specificity and sensitivity of OCT by identifying unique optical radiomic signatures pertinent to melanoma detection. We evaluate the performance of the algorithm using several tissue-mimicking phantoms. We then test the OPE algorithm with sixty-nine human subjects and demonstrate that melanoma can be differentiated from benign nevi with 97% sensitivity, and 98% specificity.
Original languageEnglish
Title of host publicationProceedings of SPIE : Optical Coherence Imaging Techniques and Imaging in Scattering Media III
Number of pages4
Publication date2019
Article number110780O
DOIs
Publication statusPublished - 2019
EventOptical Coherence Imaging Techniques and Imaging in Scattering Media III - ICM─International Congress Center, Munich, Austria
Duration: 25 Jun 201927 Jun 2019
Conference number: 3

Conference

ConferenceOptical Coherence Imaging Techniques and Imaging in Scattering Media III
Number3
LocationICM─International Congress Center
CountryAustria
CityMunich
Period25/06/201927/06/2019
SeriesProceedings of SPIE, the International Society for Optical Engineering
Volume11078
ISSN0277-786X

Cite this

Turani, Z., Fatemizadeh, E., Blumetti, T., Daveluy, S., Moraes, A. F., Chen, W., ... Nasiriavanaki, M. (2019). Optical radiomic signatures derived from OCT images to improve identification of melanoma. In Proceedings of SPIE: Optical Coherence Imaging Techniques and Imaging in Scattering Media III [110780O] Proceedings of SPIE, the International Society for Optical Engineering, Vol.. 11078 https://doi.org/10.1117/12.2526624