Only small fractions of soluble ß-glucan modulate the mucosal immune system in carp (Cyprinus carpio L.)

For decades the ability of β-glucans to modulate immunity through activation of innate cellular components has been observed. However, toxicological effects associated with the systemic administration and dose-related immune-suppression has also been described. The superior aim of this study is to understand the effect of β-glucan induced modulation in carp in relation to tissue regeneration, mucosal immunity and host-pathogen interactions. Expression profiles of immune related genes will be measured in fresh water specie – common carp (Cyprinus carpio L.). The methodology of the project involves the usage of real-time quantitative PCR to quantify expression of genes of interest (IL-1β, IL-10, TNF-α, IL-6). This study will provide further understanding on the effect of β-glucan as a modulator which could improve fish welfare and health as well as having an economic potential production for the aquaculture industry.