On the use of envelope following responses to estimate peripheral level compression in the auditory system

Gerard Encina-Llamas*, Torsten Dau, Bastian Epp

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Individual estimates of cochlear compression may provide complementary information to traditional audiometric hearing thresholds in disentangling different types of peripheral cochlear damage. Here we investigated the use of the slope of envelope following response (EFR) magnitude-level functions obtained from four simultaneously presented amplitude modulated tones with modulation frequencies of 80–100 Hz as a proxy of peripheral level compression. Compression estimates in individual normal hearing (NH) listeners were consistent with previously reported group-averaged compression estimates based on psychoacoustical and distortion-product oto-acoustic emission (DPOAE) measures in human listeners. They were also similar to basilar membrane (BM) compression values measured invasively in non-human mammals. EFR-based compression estimates in hearing-impaired listeners were less compressive than those for the NH listeners, consistent with a reduction of BM compression. Cochlear compression was also estimated using DPOAEs in the same NH listeners. DPOAE estimates were larger (less compressive) than EFRs estimates, showing no correlation. Despite the numerical concordance between EFR-based compression estimates and group-averaged estimates from other methods, simulations using an auditory nerve (AN) model revealed that compression estimates based on EFRs might be highly influenced by contributions from off-characteristic frequency (CF) neural populations. This compromises the possibility to estimate on-CF (i.e., frequency-specific or “local”) peripheral level compression with EFRs.

Original languageEnglish
Article number6962
JournalScientific Reports
Volume11
Issue number1
Number of pages19
ISSN2045-2322
DOIs
Publication statusPublished - 2021

Bibliographical note

Funding Information:
The authors wish to thank to James M. Harte from Interacoustics Research Unit (IRU) for his valuable comments and discussions. We are also thankful to Ian C. Bruce for facilitating us with a version of the AN model that outputs the response of the BM module. We are grateful to two anonymous reviewers for their very valuable comments that certainly improved our manuscript. This work was supported by the Oticon Centre of Excellence for Hearing and Speech Sciences (CHeSS) and the Novo Nordisk Foundation grant NNF17OC0027872 at the Technical University of Denmark (DTU).

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