Abstract
Dissolution-DNP is a method to create solutions of molecules with nuclear spin polarization close to unity. The many orders of magnitude signal enhancement have enabled many new applications, in particular in vivo MR metabolic imaging. The method relies on solid state dynamic nuclear polarization at low temperature followed by a dissolution to produce the room temperature solution of highly polarized spins. This work describes the present and future of dissolution-DNP in the mind of the author. The article describes some of the current trends in the field as well as outlines some of the areas where new ideas will make an impact. Most certainly, the future will take unpredicted directions, but hopefully the thoughts presented here will stimulate new ideas that can further advance the field. (C) 2016 Elsevier Inc. All rights reserved.
| Original language | English |
|---|---|
| Journal | Journal of Magnetic Resonance |
| Volume | 264 |
| Pages (from-to) | 3-12 |
| ISSN | 1090-7807 |
| DOIs | |
| Publication status | Published - 2016 |
Keywords
- Biophysics
- Biochemistry
- Nuclear and High Energy Physics
- Condensed Matter Physics
- Dissolution-DNP
- Hyperpolarization
- Polarizer
- Dissolution
- Polarization
- Temperature
- Dissolution DNP
- Metabolic imaging
- Nuclear-spin polarization
- Orders of magnitude
- Signal enhancement
- Solid state dynamics
- Spin polarization
- Magnetic resonance spectrometers, auxiliary instruments and techniques
- dynamic nuclear polarisation
- magnetic resonance imaging
- dissolution-DNP
- nuclear spin polarization
- magnitude signal enhancement
- MR metabolic imaging
- solid state dynamic nuclear polarization
- BIOCHEMICAL
- PHYSICS,
- SPECTROSCOPY
- DYNAMIC-NUCLEAR-POLARIZATION
- LIQUID-STATE NMR
- PARA-HYDROGEN
- SENSITIVITY
- PERFORMANCE
- RESONANCE
- INJECTION
- MRI
- HYPERPOLARIZATION