On the Nature of the Intrinsic Connectivity of the Cat Motor Cortex: Evidence for a Recurrent Neural Network Topology

Charles Capaday, C Ethier, L Brizzi, A Sik, C van Vreeswijk, D Gingras

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Abstract

Capaday C, Ethier C, Brizzi L, Sik A, van Vreeswijk C, Gingras D. On the nature of the intrinsic connectivity of the cat motor cortex: evidence for a recurrent neural network topology. J Neurophysiol 102: 2131-2141, 2009. First published July 22, 2009; doi: 10.1152/jn.91319.2008. The details and functional significance of the intrinsic horizontal connections between neurons in the motor cortex (MCx) remain to be clarified. To further elucidate the nature of this intracortical connectivity pattern, experiments were done on the MCx of three cats. The anterograde tracer biocytin was ejected iontophoretically in layers II, III, and V. Some 30-50 neurons within a radius of similar to 250 mu m were thus stained. The functional output of the motor cortical point at which biocytin was injected, and of the surrounding points, was identified by microstimulation and electromyographic recordings. The axonal arborizations of the stained neurons were traced under camera lucida. The axon collaterals were extensive, reaching distances of
Original languageEnglish
JournalJournal of Neurophysiology
Volume104
Issue number4
Pages (from-to)2131-2141
ISSN0022-3077
DOIs
Publication statusPublished - 2009

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