On the influence of oxygen and cell concentration in an SFPR whole-cell biocatalytic Baeyer-Villiger oxidation process

I Hilker, C Baldwin, V Alphand, R Furstoss, John Woodley, R Wohlgemuth

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Efficient whole cell biotransformations, in particular microbial whole cell Baeyer-Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer-Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. (c) 2006 Wiley Periodicals, Inc.
Original languageEnglish
JournalBiotechnology and Bioengineering
Volume93
Issue number6
Pages (from-to)1138-1144
ISSN0006-3592
DOIs
Publication statusPublished - 2006
Externally publishedYes

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