On the influence of oxygen and cell concentration in an SFPR whole-cell biocatalytic Baeyer-Villiger oxidation process

I Hilker; C Baldwin; V Alphand; R Furstoss; John Woodley; R Wohlgemuth

doi:10.1002/bit.20829

On the influence of oxygen and cell concentration in an SFPR whole-cell biocatalytic Baeyer-Villiger oxidation process

I Hilker, C Baldwin, V Alphand, R Furstoss, John Woodley, R Wohlgemuth

University College London

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Efficient whole cell biotransformations, in particular microbial whole cell Baeyer-Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer-Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. (c) 2006 Wiley Periodicals, Inc.

Original language	English
Journal	Biotechnology and Bioengineering
Volume	93
Issue number	6
Pages (from-to)	1138-1144
ISSN	0006-3592
DOIs	https://doi.org/10.1002/bit.20829
Publication status	Published - 2006
Externally published	Yes

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AU - Hilker, I

AU - Baldwin, C

AU - Alphand, V

AU - Furstoss, R

AU - Woodley, John

AU - Wohlgemuth, R

PY - 2006

Y1 - 2006

N2 - Efficient whole cell biotransformations, in particular microbial whole cell Baeyer-Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer-Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. (c) 2006 Wiley Periodicals, Inc.

AB - Efficient whole cell biotransformations, in particular microbial whole cell Baeyer-Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer-Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. (c) 2006 Wiley Periodicals, Inc.

U2 - 10.1002/bit.20829

DO - 10.1002/bit.20829

M3 - Journal article

SN - 0006-3592

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JO - Biotechnology and Bioengineering

JF - Biotechnology and Bioengineering

IS - 6

ER -

On the influence of oxygen and cell concentration in an SFPR whole-cell biocatalytic Baeyer-Villiger oxidation process

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