Omics based comparative analysis of putative Mobile Genetic Elements in Lactococcus lactis

Joakim Mark Andersen*, Christine Møller Pedersen, Claus Heiner Bang-Berthelsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Lactococcus lactis is globally used in food fermentation. Genomics is useful to investigate speciation and differential occurrence of (un)desired gene functions, often related to mobile DNA. This study investigates L. lactis for putative chromosomal mobile genetic elements through comparative genomics, and analyse how they contribute to chromosomal variation at strain level. Our work identified 95 loci may range over 10% of the chromosome size when including prophages and the loci display a marked differential occurrence in the analysed strains. Analysis of differential transcriptomics data revealed how mobile genetic elements may impact the host physiology in response to conditional changes. The insight in the genetic variation of mobile genetic elements in L. lactis holds potential to further identify important functions related to food and biotechnology applications within this important species.
Original languageEnglish
Article numberfnz102
JournalFEMS Microbiology Letters
Volume366
Issue number9
Number of pages9
ISSN0378-1097
DOIs
Publication statusPublished - 2019

Keywords

  • comparative genomics
  • lactococcus lactis
  • mobile genetic elements
  • sRNA
  • speciation
  • transcriptomics

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