TY - JOUR
T1 - Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms
AU - Palazzotto, Emilia
AU - Weber, Tilmann
PY - 2018
Y1 - 2018
N2 - Natural products produced by microorganisms represent the main source of bioactive molecules. The development of high-throughput (omics) techniques have importantly contributed to the renaissance of new antibiotic discovery increasing our understanding of complex mechanisms controlling the expression of biosynthetic gene clusters (BGCs) encoding secondary metabolites. In this context this review highlights recent progress in the use and integration of ‘omics’ approaches with focuses on genomics, transcriptomics, proteomics metabolomics meta-omics and combined omics as powerful strategy to discover new antibiotics.
AB - Natural products produced by microorganisms represent the main source of bioactive molecules. The development of high-throughput (omics) techniques have importantly contributed to the renaissance of new antibiotic discovery increasing our understanding of complex mechanisms controlling the expression of biosynthetic gene clusters (BGCs) encoding secondary metabolites. In this context this review highlights recent progress in the use and integration of ‘omics’ approaches with focuses on genomics, transcriptomics, proteomics metabolomics meta-omics and combined omics as powerful strategy to discover new antibiotics.
U2 - 10.1016/j.mib.2018.03.004
DO - 10.1016/j.mib.2018.03.004
M3 - Journal article
C2 - 29656009
SN - 1369-5274
VL - 45
SP - 109
EP - 116
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -