@inproceedings{82072b330d6945aaaa52be24dc04c378,
title = "Numerical Modeling of Gas-liquid Hydrodynamics in a U-loop Bioreactor",
abstract = "A numerical model of a U-loop bioreactor is developed, with the aim of replicating the mass transfer characteristics of the real system. The bioreactor model includes a multiphase fluid dynamic model, coupled with a population balance model, to simulate the dispersed bubbles in the loop and estimate the gas-liquid interfacial surface area. The results from the numerical model are compared to experimental measurements of the mass transfer coefficient in the downgoing leg of the U-loop. The numerical model of the U-loop bioreactor is able to replicate the qualitative behavior of KLa as function of the operating parameters: liquid circulation, gas flow and bottom pressure, however the dependency on operational conditions is under-valued. Further validation of the individual models is required to develop more realistic and robust models, and will contribute to understanding the physical phenomena taking place in a U-loop. The numerical model also provides insights into the qualitative behavior of the multiphase flow in a U-loop bioreactor.",
keywords = "Gas fermentation, Static Mixer, Computational Fluid Dynamics (CFD)",
author = "\{de Carfort\}, \{Johan le Nepvou\} and Tiago Pinto and Ulrich Kr{\"u}hne",
year = "2023",
doi = "10.1016/B978-0-443-15274-0.50124-4",
language = "English",
isbn = "978-0-443-23553-5",
volume = "52",
series = "Computer Aided Chemical Engineering",
publisher = "Elsevier",
pages = "775--781",
editor = "Kokossis, \{Antonis \} and \{C. Georgiadis\}, \{Michael \} and \{N. Pistikopoulos\}, Efstratios",
booktitle = "Proceedings of the 33rd European Symposium on Computer Aided Process Engineering",
address = "United Kingdom",
note = "33rd European Symposium on Computer Aided Process Engineering, ESCAPE33 ; Conference date: 18-06-2023 Through 21-06-2023",
}