Nucleotide metabolism in Lactococcus lactis: Salvage pathways of exogenous pyrimidines

Jan Martinussen, Paal Skytt Andersen, Karin Hammer

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    By measuring enzyme activities in crude extracts and studying the effect of toxic analogs (5-fluoropyrimidines) on cell growth, the metabolism of pyrimidines in Lactococcus lactis was analyzed. Pathways by which uracil, uridine, deoxyuridine, cytidine, and deoxycytidine are metabolized in L. lactis were established. They are similar to those found in Escherichia coli except that lactococci are unable to utilize cytosine.
    Original languageEnglish
    JournalJournal of Bacteriology
    Volume176
    Issue number5
    Pages (from-to)1514-1516
    Number of pages3
    ISSN0021-9193
    Publication statusPublished - 1994

    Keywords

    • Cytidine
    • Deoxycytidine
    • Deoxyuridine
    • Enzymes
    • Escherichia coli
    • Kinetics
    • Lactococcus lactis
    • Pyrimidines
    • Species Specificity
    • Uracil
    • Uridine
    • 0W860991D6 Deoxycytidine
    • 56HH86ZVCT Uracil
    • 5CSZ8459RP Cytidine
    • W78I7AY22C Deoxyuridine
    • WHI7HQ7H85 Uridine
    • CYTIDINE
    • DEOXYCYTIDINE
    • DEOXYURIDINE
    • URACIL
    • URIDINE
    • Eubacteria Bacteria Microorganisms (Bacteria, Eubacteria, Microorganisms) - Gram-Positive Cocci [07700] gram-positive cocci Lactococcus lactis
    • CYTIDINE 65-46-3
    • DEOXYCYTIDINE 951-77-9
    • DEOXYURIDINE 951-78-0
    • PYRIMIDINES 289-95-2D
    • URACIL 66-22-8
    • URIDINE 58-96-8
    • 10062, Biochemistry studies - Nucleic acids, purines and pyrimidines
    • 10506, Biophysics - Molecular properties and macromolecules
    • 13014, Metabolism - Nucleic acids, purines and pyrimidines
    • 31000, Physiology and biochemistry of bacteria
    • Metabolism
    • Physiology
    • LACTOCOCCUS lactis

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