Nucleotide Metabolism

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    Abstract

    Metabolic pathways are connected through their utilization of nucleotides as supplier of energy, allosteric effectors, and their role in activation of intermediates. Therefore, any attempt to exploit a given living organism in a biotechnological process will have an impact on nucleotide metabolism and vice versa. Here, we provide an overview of the pyrimidine and purine biosynthesis, the interconversion pathways, the formation of deoxyribonucleotides, and the salvage reactions used in the utilization of exogenous precursors. The enzymatic and genetic regulation of these pathways are addressed. The aim of this article is to provide knowledge of nucleotide metabolism and its regulation to facilitate interpretation of data arising from genetics, proteomics, and transcriptomics in connection with biotechnological processes and beyond.
    Original languageEnglish
    Title of host publicationComprehensive Biotechnology
    EditorsMurray Moo-Young
    Volume1
    PublisherElsevier
    Publication date2011
    Edition2
    Pages91-107
    ISBN (Print)978-0-08-088504-9
    Publication statusPublished - 2011

    Keywords

    • Nucleotide salvage
    • ATP
    • dATP
    • GTP
    • Purines
    • dGTP
    • Nucleotide biosynthesis
    • UTP
    • dCTP
    • Pyrimidines
    • dTTP
    • Nucleotide interconversion
    • CTP
    • Regulation of gene expression

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