TY - JOUR
T1 - Nuclear magnetic resonance-based metabonomics reveals strong sex effect on plasma metabolism in 17-year-old Scandinavians and correlation to retrospective infant plasma parameters
AU - Bertram, Hanne Christine
AU - Duus, Jens Øllgaard
AU - Petersen, Bent O.
AU - Hoppe, Camilla
AU - Larnkjaer, Anni
AU - Schack-Nielsen, Lene
AU - Mølgaard, Christian
AU - Michaelsen, Kim. F.
PY - 2009
Y1 - 2009
N2 - Nuclear magnetic resonance (WR)-based metabonomics was carried out on plasma samples from a total of seventy-five 17-year-old Danes to investigate the impact of key parameters such as sex, height, weight, and body mass index on the plasma metabolite profile in a normal, healthy population. Principal component analysis identified sex to have a large impact on the NMR plasma metabolome, whereas no apparent effects of height, weight, and body mass index were found. Partial least square regression discriminant analysis and quantification of relative metabolite concentrations by integration of NMR signals revealed that the sex effect included differences in plasma lipoproteins (mainly high-density lipoprotein), glucose, choline, and amino acid content. Accordingly, the present study suggests a higher lipid synthesis in young women than young men and a higher protein turnover in Young men compared with women. Data on plasma content of triglyceride, lipoprotein fractions, and cholesterol at an age of 9 months were available for selected individuals (n = 40),- and partial least square regressions revealed correlations between these infant parameters and the NMR plasma metabolome at an age of 17 years. In conclusion, the present study demonstrates the feasibility of NMR-based metabonomics for obtaining a deeper insight into interindividual differences in metabolism and for exploring relationships between parameters measured early in life and metabolic status at a later stage. (C) 2009 Elsevier Inc. All rights reserved.
AB - Nuclear magnetic resonance (WR)-based metabonomics was carried out on plasma samples from a total of seventy-five 17-year-old Danes to investigate the impact of key parameters such as sex, height, weight, and body mass index on the plasma metabolite profile in a normal, healthy population. Principal component analysis identified sex to have a large impact on the NMR plasma metabolome, whereas no apparent effects of height, weight, and body mass index were found. Partial least square regression discriminant analysis and quantification of relative metabolite concentrations by integration of NMR signals revealed that the sex effect included differences in plasma lipoproteins (mainly high-density lipoprotein), glucose, choline, and amino acid content. Accordingly, the present study suggests a higher lipid synthesis in young women than young men and a higher protein turnover in Young men compared with women. Data on plasma content of triglyceride, lipoprotein fractions, and cholesterol at an age of 9 months were available for selected individuals (n = 40),- and partial least square regressions revealed correlations between these infant parameters and the NMR plasma metabolome at an age of 17 years. In conclusion, the present study demonstrates the feasibility of NMR-based metabonomics for obtaining a deeper insight into interindividual differences in metabolism and for exploring relationships between parameters measured early in life and metabolic status at a later stage. (C) 2009 Elsevier Inc. All rights reserved.
U2 - 10.1016/j.metabol.2009.03.011
DO - 10.1016/j.metabol.2009.03.011
M3 - Journal article
C2 - 19411084
SN - 0026-0495
VL - 58
SP - 1039
EP - 1045
JO - Metabolism
JF - Metabolism
IS - 7
ER -