TY - JOUR
T1 - Novel self-associative and multiphase nanostructured soft carriers based on amphiphilic hyaluronic acid derivatives
AU - Eenschooten, Corinne
AU - Vaccaro, Andrea
AU - Delie, Florence
AU - Guillaumie, Fanny
AU - Tømmeraas, Kristoffer
AU - Kontogeorgis, Georgios
AU - Schwach-Abdellaoui, Khadija
AU - Borkovec, Michal
AU - Gurny, Robert
PY - 2012
Y1 - 2012
N2 - The purpose of the present study was to investigate the physicochemical properties in aqueous media of
amphiphilic hyaluronic acid (HA) derivatives obtained by reaction of HA’s hydroxyl groups with octenyl
succinic anhydride (OSA). The self-associative properties of the resulting octenyl succinic anhydridemodified
hyaluronic acid (OSA-HA) derivatives were studied by fluorescence spectroscopy using Nile
Red as fluorophore. The morphology, size and surface charge of the OSA-HA assemblies were determined
by transmission electron microscopy, dynamic light scattering and by measuring their electrophoretic
mobility, respectively. OSA-HA was shown to spontaneously self-associate in aqueous media into negatively
charged spherical and multiphasic nanostructures with a hydrodynamic diameter between 170 and
230 nm and to solubilize hydrophobic compounds such as Nile Red. This was a good indication that OSAHA
could be used as building block for the formulation of soft nanocarriers towards the encapsulation
and controlled delivery of hydrophobic active ingredients or drugs.
AB - The purpose of the present study was to investigate the physicochemical properties in aqueous media of
amphiphilic hyaluronic acid (HA) derivatives obtained by reaction of HA’s hydroxyl groups with octenyl
succinic anhydride (OSA). The self-associative properties of the resulting octenyl succinic anhydridemodified
hyaluronic acid (OSA-HA) derivatives were studied by fluorescence spectroscopy using Nile
Red as fluorophore. The morphology, size and surface charge of the OSA-HA assemblies were determined
by transmission electron microscopy, dynamic light scattering and by measuring their electrophoretic
mobility, respectively. OSA-HA was shown to spontaneously self-associate in aqueous media into negatively
charged spherical and multiphasic nanostructures with a hydrodynamic diameter between 170 and
230 nm and to solubilize hydrophobic compounds such as Nile Red. This was a good indication that OSAHA
could be used as building block for the formulation of soft nanocarriers towards the encapsulation
and controlled delivery of hydrophobic active ingredients or drugs.
KW - Drug delivery
KW - Hyaluronic acid
KW - Self-assembly
KW - Physicochemical properties
KW - Derivative
KW - Polymeric nanogel
U2 - 0.1016/j.carbpol.2011.08.004
DO - 0.1016/j.carbpol.2011.08.004
M3 - Journal article
SN - 0144-8617
VL - 87
SP - 444
EP - 451
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -