Novel self-associative and multiphase nanostructured soft carriers based on amphiphilic hyaluronic acid derivatives

Corinne Eenschooten, Andrea Vaccaro, Florence Delie, Fanny Guillaumie, Kristoffer Tømmeraas, Georgios Kontogeorgis, Khadija Schwach-Abdellaoui, Michal Borkovec, Robert Gurny

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The purpose of the present study was to investigate the physicochemical properties in aqueous media of amphiphilic hyaluronic acid (HA) derivatives obtained by reaction of HA’s hydroxyl groups with octenyl succinic anhydride (OSA). The self-associative properties of the resulting octenyl succinic anhydridemodified hyaluronic acid (OSA-HA) derivatives were studied by fluorescence spectroscopy using Nile Red as fluorophore. The morphology, size and surface charge of the OSA-HA assemblies were determined by transmission electron microscopy, dynamic light scattering and by measuring their electrophoretic mobility, respectively. OSA-HA was shown to spontaneously self-associate in aqueous media into negatively charged spherical and multiphasic nanostructures with a hydrodynamic diameter between 170 and 230 nm and to solubilize hydrophobic compounds such as Nile Red. This was a good indication that OSAHA could be used as building block for the formulation of soft nanocarriers towards the encapsulation and controlled delivery of hydrophobic active ingredients or drugs.
Original languageEnglish
JournalCarbohydrate Polymers
Volume87
Pages (from-to)444-451
ISSN0144-8617
DOIs
Publication statusPublished - 2012

Keywords

  • Drug delivery
  • Hyaluronic acid
  • Self-assembly
  • Physicochemical properties
  • Derivative
  • Polymeric nanogel

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