Novel Adjuvants and Immunomodulators for Veterinary Vaccines

Peter M. H. Heegaard, Yongxiang Fang, Gregers Jungersen

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    Abstract

    Adjuvants are crucial for efficacy of vaccines, especially subunit and recombinant vaccines. Rational vaccine design, including knowledge-based and molecularly defined adjuvants tailored for directing and potentiating specific types of host immune responses towards the antigens included in the vaccine is becoming a reality with our increased understanding of innate and adaptive immune activation. This will allow future vaccines to induce immune reactivity having adequate specificity as well as protective and recallable immune effector mechanisms in appropriate body compartments, including mucosal surfaces. Here we describe these new developments and, when possible, relate new immunological knowledge to the many years of experience with traditional, empirical adjuvants. Finally, some protocols are given for production of emulsion (oil-based) and liposome-based adjuvant/antigen formulations.
    Original languageEnglish
    Title of host publicationVaccine Technologies for Veterinary Viral Diseases : Methods and Protocols
    EditorsAlejandro Brun
    Number of pages20
    Place of PublicationNew York
    PublisherSpringer Science+Business Media
    Publication date2016
    Pages63-82
    Chapter5
    DOIs
    Publication statusPublished - 2016
    SeriesMethods in Molecular Biology
    Volume1349
    ISSN1064-3745

    Keywords

    • Adjuvant
    • Immunomodulator
    • Innate immune system
    • Protective immune responses
    • Vaccination

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