Nonparametric Analysis of Nonlinear Distortions for Biomolecular Systems

Atul Agarwal, Abhishek Dey, Rishi Relan*, Shaunak Sen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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System identification of biomolecular circuits is a challenging problem, including due to the nonlinearities that are often present in them. The extent to which these nonlinearities contribute to the overall behaviour of the biomolecular circuit is unclear. Here, we address this issue for simple biomolecular circuit models by exploiting the properties of broadband random phase multisine excitations. We analysed the classical models of a two-state signaling system, an enzymatic signaling system, and of a transcriptional feedback circuit for the presence of nonlinear distortions at certain parametric settings and studied their dependence on the input parameters. These results should help the modeller in quantifying the effect of nonlinearities and assessing the validity of the linear models at a particular operating condition.
Original languageEnglish
Book seriesI F A C Workshop Series
Issue number1
Pages (from-to)313-318
Publication statusPublished - 2018


  • System identification
  • Biomolecular system


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