Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Leticia Hosta Rigau, Rona Chandrawati, Elli Saveriades, Pascal D. Odermatt, Almar Postma, Francesca Ercole, Kerry Breheney, Kim L. Wark, Brigitte Stadler, Frank Caruso

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assembled similar to 1 mu m diameter PMA(c)-based capsosomes, polymer hydrogel capsules that contain up to similar to 2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.
Original languageEnglish
JournalBiomacromolecules
Volume11
Issue number12
Pages (from-to)3548-3555
Number of pages8
ISSN1525-7797
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • BIOCHEMISTRY
  • CHEMISTRY,
  • POLYMER
  • POLYMER HYDROGEL CAPSULES
  • COLORECTAL-CANCER CELLS
  • ENZYME-LOADED LIPOSOMES
  • POLYELECTROLYTE MICROCAPSULES
  • MULTILAYERED PARTICLES
  • ACRYLIC-ACID
  • EN-ROUTE
  • CARRIERS
  • TEMPLATES
  • SYSTEMS
  • Antineoplastic Agents
  • Capsules
  • Cell Line, Tumor
  • Cell Survival
  • Depsipeptides
  • Drug Carriers
  • Drug Delivery Systems
  • Humans
  • Hydrogels
  • Liposomes
  • Lung Neoplasms
  • Miniaturization
  • Paclitaxel
  • Polymethacrylic Acids
  • thiocoraline
  • Drug delivery
  • Drug products
  • Encapsulation
  • Phospholipids
  • Polymers
  • Polyacrylates
  • capsosome
  • liposome
  • methacrylic acid derivative
  • oleyl methacrylic acid
  • paclitaxel
  • polymer
  • unclassified drug
  • adsorption
  • article
  • cell viability
  • desorption
  • drug delivery system
  • encapsulation
  • human
  • human cell
  • priority journal
  • Antitumor compounds
  • Cholesteryl methacrylate
  • Concentration-dependent
  • Insoluble drug
  • Lung cancer cells
  • Noncovalent
  • Poly (methacrylic acid)
  • Polymer hydrogels
  • Polymer layers
  • Potential drug
  • polymerization
  • Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] A549 cell line cell_line human lung carcinoma cells
  • paclitaxel 33069-62-4 antineoplastic-drug
  • thiocoraline 173046-02-1 antineoplastic-drug
  • 02508, Cytology - Human
  • 10060, Biochemistry studies - General
  • 10511, Biophysics - Bioengineering
  • 12512, Pathology - Therapy
  • 22002, Pharmacology - General
  • 24008, Neoplasms - Therapeutic agents and therapy
  • Pharmacology
  • poly(methacrylic acid)-co-(cholesteryl methacrylate)-based capsosome drug delivery device
  • Biomaterials
  • Pharmaceuticals

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