Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Leticia Hosta Rigau; Rona Chandrawati; Elli Saveriades; Pascal D. Odermatt; Almar Postma; Francesca Ercole; Kerry Breheney; Kim L. Wark; Brigitte Stadler; Frank Caruso

doi:10.1021/bm101020e

Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Leticia Hosta Rigau, Rona Chandrawati, Elli Saveriades, Pascal D. Odermatt, Almar Postma, Francesca Ercole, Kerry Breheney, Kim L. Wark, Brigitte Stadler, Frank Caruso

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assembled similar to 1 mu m diameter PMA(c)-based capsosomes, polymer hydrogel capsules that contain up to similar to 2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.

Original language	English
Journal	Biomacromolecules
Volume	11
Issue number	12
Pages (from-to)	3548-3555
Number of pages	8
ISSN	1525-7797
DOIs	https://doi.org/10.1021/bm101020e
Publication status	Published - 2010
Externally published	Yes

Keywords

BIOCHEMISTRY
CHEMISTRY,
POLYMER
POLYMER HYDROGEL CAPSULES
COLORECTAL-CANCER CELLS
ENZYME-LOADED LIPOSOMES
POLYELECTROLYTE MICROCAPSULES
MULTILAYERED PARTICLES
ACRYLIC-ACID
EN-ROUTE
CARRIERS
TEMPLATES
SYSTEMS
Antineoplastic Agents
Capsules
Cell Line, Tumor
Cell Survival
Depsipeptides
Drug Carriers
Drug Delivery Systems
Humans
Hydrogels
Liposomes
Lung Neoplasms
Miniaturization
Paclitaxel
Polymethacrylic Acids
thiocoraline
Drug delivery
Drug products
Encapsulation
Phospholipids
Polymers
Polyacrylates
capsosome
liposome
methacrylic acid derivative
oleyl methacrylic acid
paclitaxel
polymer
unclassified drug
adsorption
article
cell viability
desorption
drug delivery system
encapsulation
human
human cell
priority journal
Antitumor compounds
Cholesteryl methacrylate
Concentration-dependent
Insoluble drug
Lung cancer cells
Noncovalent
Poly (methacrylic acid)
Polymer hydrogels
Polymer layers
Potential drug
polymerization
Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] A549 cell line cell_line human lung carcinoma cells
paclitaxel 33069-62-4 antineoplastic-drug
thiocoraline 173046-02-1 antineoplastic-drug
02508, Cytology - Human
10060, Biochemistry studies - General
10511, Biophysics - Bioengineering
12512, Pathology - Therapy
22002, Pharmacology - General
24008, Neoplasms - Therapeutic agents and therapy
Pharmacology
poly(methacrylic acid)-co-(cholesteryl methacrylate)-based capsosome drug delivery device
Biomaterials
Pharmaceuticals

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/bm101020e

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title = "Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery",

abstract = "We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assembled similar to 1 mu m diameter PMA(c)-based capsosomes, polymer hydrogel capsules that contain up to similar to 2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.",

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author = "Rigau, {Leticia Hosta} and Rona Chandrawati and Elli Saveriades and Odermatt, {Pascal D.} and Almar Postma and Francesca Ercole and Kerry Breheney and Wark, {Kim L.} and Brigitte Stadler and Frank Caruso",

year = "2010",

doi = "10.1021/bm101020e",

language = "English",

volume = "11",

pages = "3548--3555",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

number = "12",

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TY - JOUR

T1 - Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

AU - Rigau, Leticia Hosta

AU - Chandrawati, Rona

AU - Saveriades, Elli

AU - Odermatt, Pascal D.

AU - Postma, Almar

AU - Ercole, Francesca

AU - Breheney, Kerry

AU - Wark, Kim L.

AU - Stadler, Brigitte

AU - Caruso, Frank

PY - 2010

Y1 - 2010

N2 - We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assembled similar to 1 mu m diameter PMA(c)-based capsosomes, polymer hydrogel capsules that contain up to similar to 2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.

AB - We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assembled similar to 1 mu m diameter PMA(c)-based capsosomes, polymer hydrogel capsules that contain up to similar to 2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.

KW - BIOCHEMISTRY

KW - CHEMISTRY,

KW - POLYMER

KW - POLYMER HYDROGEL CAPSULES

KW - COLORECTAL-CANCER CELLS

KW - ENZYME-LOADED LIPOSOMES

KW - POLYELECTROLYTE MICROCAPSULES

KW - MULTILAYERED PARTICLES

KW - ACRYLIC-ACID

KW - EN-ROUTE

KW - CARRIERS

KW - TEMPLATES

KW - SYSTEMS

KW - Antineoplastic Agents

KW - Capsules

KW - Cell Line, Tumor

KW - Cell Survival

KW - Depsipeptides

KW - Drug Carriers

KW - Drug Delivery Systems

KW - Humans

KW - Hydrogels

KW - Liposomes

KW - Lung Neoplasms

KW - Miniaturization

KW - Paclitaxel

KW - Polymethacrylic Acids

KW - thiocoraline

KW - Drug delivery

KW - Drug products

KW - Encapsulation

KW - Phospholipids

KW - Polymers

KW - Polyacrylates

KW - capsosome

KW - liposome

KW - methacrylic acid derivative

KW - oleyl methacrylic acid

KW - paclitaxel

KW - polymer

KW - unclassified drug

KW - adsorption

KW - article

KW - cell viability

KW - desorption

KW - drug delivery system

KW - encapsulation

KW - human

KW - human cell

KW - priority journal

KW - Antitumor compounds

KW - Cholesteryl methacrylate

KW - Concentration-dependent

KW - Insoluble drug

KW - Lung cancer cells

KW - Noncovalent

KW - Poly (methacrylic acid)

KW - Polymer hydrogels

KW - Polymer layers

KW - Potential drug

KW - polymerization

KW - Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] A549 cell line cell_line human lung carcinoma cells

KW - paclitaxel 33069-62-4 antineoplastic-drug

KW - thiocoraline 173046-02-1 antineoplastic-drug

KW - 02508, Cytology - Human

KW - 10060, Biochemistry studies - General

KW - 10511, Biophysics - Bioengineering

KW - 12512, Pathology - Therapy

KW - 22002, Pharmacology - General

KW - 24008, Neoplasms - Therapeutic agents and therapy

KW - Pharmacology

KW - poly(methacrylic acid)-co-(cholesteryl methacrylate)-based capsosome drug delivery device

KW - Biomaterials

KW - Pharmaceuticals

U2 - 10.1021/bm101020e

DO - 10.1021/bm101020e

M3 - Journal article

C2 - 21090570

SN - 1525-7797

VL - 11

SP - 3548

EP - 3555

JO - Biomacromolecules

JF - Biomacromolecules

IS - 12

ER -

Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Abstract

Keywords

UN SDGs

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