Non-uniform tube representation of proteins

Mikael Sonne Hansen

    Research output: Contribution to conferencePosterResearch

    Abstract

    Treating the full protein structure is often neither computationally nor physically possible. Instead one is forced to consider various reduced models capturing the properties of interest. Previous work have used tubular neighborhoods of the C-alpha backbone. However, assigning a unique radius might not correctly capture volume exclusion - of crucial importance when trying to understand a proteins $3$d-structure. We propose a new reduced model treating the protein as a non-uniform tube with a radius reflecting the positions of atoms. The tube representation is well suited considering X-ray crystallographic resolution ~ 3Å while a varying radius accounts for the different sizes of side chains. Such a non-uniform tube better capture the protein geometry and has numerous applications in structural/computational biology from the classification of protein structures to sequence-structure prediction.
    Original languageEnglish
    Publication date2005
    Publication statusPublished - 2005
    EventPhysics of Life : From Single Molecules to Networks - Krogerup Højskole
    Duration: 1 Jan 2005 → …

    Conference

    ConferencePhysics of Life : From Single Molecules to Networks
    CityKrogerup Højskole
    Period01/01/2005 → …

    Cite this

    Hansen, M. S. (2005). Non-uniform tube representation of proteins. Poster session presented at Physics of Life : From Single Molecules to Networks, Krogerup Højskole, .