Non-Invasive Assessment of Intravascular Pressure Gradients: A Review of Current and Proposed Novel Methods

Tin-Quoc Nguyen*, Kristoffer Hansen, Thor Bechsgaard, Lars Lönn, Jørgen Arendt Jensen, Michael Nielsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Invasive catheterization is associated with a low risk of serious complications. However, although it is the gold standard for measuring pressure gradients, it induces changes to blood flow and requires significant resources. Therefore, non-invasive alternatives are urgently needed. Pressure gradients are routinely estimated non-invasively in clinical settings using ultrasound and calculated with the simplified Bernoulli equation, a method with several limitations. A PubMed literature search on validation of non-invasive techniques was conducted, and studies were included if non-invasively estimated pressure gradients were compared with invasively measured pressure gradients in vivo. Pressure gradients were mainly estimated from velocities obtained with Doppler ultrasound or magnetic resonance imaging. Most studies used the simplified Bernoulli equation, but more recent studies have employed the expanded Bernoulli and Navier–Stokes equations. Overall, the studies reported good correlation between non-invasive estimation of pressure gradients and catheterization. Despite having strong correlations, several studies reported the non-invasive techniques to either overestimate or underestimate the invasive measurements, thus questioning the accuracy of the non-invasive methods. In conclusion, more advanced imaging techniques may be needed to overcome the shortcomings of current methods.
Original languageEnglish
Issue number5
Number of pages19
Publication statusPublished - 2019


  • Pressure gradient
  • Ultrasound
  • Magnetic resonance imaging
  • Intravascular catheterization
  • Review


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