Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces

Keitaro  Yoshimoto; Takumi  Hirase; Peter Jeppe Madsen; Steven P. Armes; Yukio  Nagasaki

doi:10.1002/marc.200900484

Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces

Keitaro Yoshimoto
, Takumi Hirase
, Peter Jeppe Madsen
, Steven P. Armes
, Yukio Nagasaki

University of Tsukuba
University of Sheffield

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Poly[2-(methacryloyloxy)ethyl phosphorylcholine] -modified gold surfaces, which have been newly prepared by a ‘grafting to’ method using a series of monosulfanyl-terminated PMPC, are characterized by protein adsorption experiments based on surface plasmon resonance spectroscop yand ellipsometry measurements. The extent of BSA adsorption on PMPC-modified surfaces was systematically reduced for thicker PMPC layers, thus the number of MPC units on the gold surface appears to be an important factor for the excellent protein resistance offered by PMPC modified gold surfaces fabricated by the ‘grafting to’ method, which is sharp contrast to that of PEG tethered chains.

Original language	English
Journal	Macromolecular Rapid Communications
Volume	30
Pages (from-to)	2136–2140
ISSN	1022-1336
DOIs	https://doi.org/10.1002/marc.200900484
Publication status	Published - 2009
Externally published	Yes

Bibliographical note

Supporting information for this article is available at the bottom of the article’s abstract page, which can be accessed from the journal’s homepage at http://www.mrc-journal.de, or from the author.

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Yoshimoto, K., Hirase, T., Jeppe Madsen, P., Armes, S. P., & Nagasaki, Y. (2009). Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces. Macromolecular Rapid Communications, 30, 2136–2140. https://doi.org/10.1002/marc.200900484

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title = "Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the {\textquoteleft}Grafting to{\textquoteright} Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces",

abstract = "Poly[2-(methacryloyloxy)ethyl phosphorylcholine] -modified gold surfaces, which have been newly prepared by a {\textquoteleft}grafting to{\textquoteright} method using a series of monosulfanyl-terminated PMPC, are characterized by protein adsorption experiments based on surface plasmon resonance spectroscop yand ellipsometry measurements. The extent of BSA adsorption on PMPC-modified surfaces was systematically reduced for thicker PMPC layers, thus the number of MPC units on the gold surface appears to be an important factor for the excellent protein resistance offered by PMPC modified gold surfaces fabricated by the {\textquoteleft}grafting to{\textquoteright} method, which is sharp contrast to that of PEG tethered chains.",

author = "Keitaro Yoshimoto and Takumi Hirase and \{Jeppe Madsen\}, Peter and Armes, \{Steven P.\} and Yukio Nagasaki",

note = "Supporting information for this article is available at the bottom of the article{\textquoteright}s abstract page, which can be accessed from the journal{\textquoteright}s homepage at http://www.mrc-journal.de, or from the author.",

year = "2009",

doi = "10.1002/marc.200900484",

language = "English",

volume = "30",

pages = "2136–2140",

journal = "Macromolecular Rapid Communications",

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Yoshimoto, K, Hirase, T, Jeppe Madsen, P, Armes, SP & Nagasaki, Y 2009, 'Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces', Macromolecular Rapid Communications, vol. 30, pp. 2136–2140. https://doi.org/10.1002/marc.200900484

Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces. / Yoshimoto, Keitaro ; Hirase, Takumi ; Jeppe Madsen, Peter et al.
In: Macromolecular Rapid Communications, Vol. 30, 2009, p. 2136–2140.

Research output: Contribution to journal › Journal article › Research › peer-review

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T1 - Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces

AU - Yoshimoto, Keitaro

AU - Hirase, Takumi

AU - Jeppe Madsen, Peter

AU - Armes, Steven P.

AU - Nagasaki, Yukio

N1 - Supporting information for this article is available at the bottom of the article’s abstract page, which can be accessed from the journal’s homepage at http://www.mrc-journal.de, or from the author.

PY - 2009

Y1 - 2009

N2 - Poly[2-(methacryloyloxy)ethyl phosphorylcholine] -modified gold surfaces, which have been newly prepared by a ‘grafting to’ method using a series of monosulfanyl-terminated PMPC, are characterized by protein adsorption experiments based on surface plasmon resonance spectroscop yand ellipsometry measurements. The extent of BSA adsorption on PMPC-modified surfaces was systematically reduced for thicker PMPC layers, thus the number of MPC units on the gold surface appears to be an important factor for the excellent protein resistance offered by PMPC modified gold surfaces fabricated by the ‘grafting to’ method, which is sharp contrast to that of PEG tethered chains.

AB - Poly[2-(methacryloyloxy)ethyl phosphorylcholine] -modified gold surfaces, which have been newly prepared by a ‘grafting to’ method using a series of monosulfanyl-terminated PMPC, are characterized by protein adsorption experiments based on surface plasmon resonance spectroscop yand ellipsometry measurements. The extent of BSA adsorption on PMPC-modified surfaces was systematically reduced for thicker PMPC layers, thus the number of MPC units on the gold surface appears to be an important factor for the excellent protein resistance offered by PMPC modified gold surfaces fabricated by the ‘grafting to’ method, which is sharp contrast to that of PEG tethered chains.

U2 - 10.1002/marc.200900484

DO - 10.1002/marc.200900484

M3 - Journal article

SN - 1022-1336

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JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

ER -

Yoshimoto K, Hirase T, Jeppe Madsen P, Armes SP, Nagasaki Y. Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces. Macromolecular Rapid Communications. 2009;30:2136–2140. doi: 10.1002/marc.200900484