NMF on positron emission tomography

Bjarni Bödvarsson; Lars Kai Hansen; Claus Svarer; Gitte Knudsen

doi:10.1109/ICASSP.2007.366678

NMF on positron emission tomography

Bjarni Bödvarsson, Lars Kai Hansen, Claus Svarer, Gitte Knudsen

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Abstract

In positron emission tomography, kinetic modelling of brain tracer uptake, metabolism or binding requires knowledge of the cerebral input function. Traditionally, this is achieved with arterial blood sampling in the arm or as shown in (Liptrot, M, et al., 2004) by non-invasive K-means clustering. We propose another method to estimate time-activity curves (TAC) extracted directly from dynamic positron emission tomography (PET) scans by non-negative matrix factorization (NMF). Since the scaling of the basis curves is lost in the NMF the estimated TAC is scaled by a vector alpha which is calculated from the NMF solution. The method is tested on a [18F]-Altanserin tracer ligand data set consisting of 5 healthy subjects. The results from using K-means clustering and NMF are compared to a sampled arterial TAC. The comparison is done by calculating the correlation with the arterial sampled TAC.

Original language	English
Title of host publication	IEEE International Conference on Acoustics, Speech and Signal Processing, 2007. ICASSP 2007.
Place of Publication	CASSP
Publisher	CASSP
Publication date	2007
ISBN (Print)	1-4244-0727-3
DOIs	https://doi.org/10.1109/ICASSP.2007.366678
Publication status	Published - 2007
Event	2007 IEEE International Conference on Acoustics, Speech and Signal Processing - Honolulu, United States Duration: 15 Apr 2007 → 20 Apr 2007 Conference number: 32

Conference

Conference	2007 IEEE International Conference on Acoustics, Speech and Signal Processing
Number	32
Country/Territory	United States
City	Honolulu
Period	15/04/2007 → 20/04/2007

Bibliographical note

Copyright: 2007 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE

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@inproceedings{4ec84856f8cf479d82a179199a2be287,

title = "NMF on positron emission tomography",

abstract = "In positron emission tomography, kinetic modelling of brain tracer uptake, metabolism or binding requires knowledge of the cerebral input function. Traditionally, this is achieved with arterial blood sampling in the arm or as shown in (Liptrot, M, et al., 2004) by non-invasive K-means clustering. We propose another method to estimate time-activity curves (TAC) extracted directly from dynamic positron emission tomography (PET) scans by non-negative matrix factorization (NMF). Since the scaling of the basis curves is lost in the NMF the estimated TAC is scaled by a vector alpha which is calculated from the NMF solution. The method is tested on a [18F]-Altanserin tracer ligand data set consisting of 5 healthy subjects. The results from using K-means clustering and NMF are compared to a sampled arterial TAC. The comparison is done by calculating the correlation with the arterial sampled TAC.",

author = "Bjarni B{\"o}dvarsson and Hansen, {Lars Kai} and Claus Svarer and Gitte Knudsen",

note = "Copyright: 2007 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE; 2007 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP 2007 ; Conference date: 15-04-2007 Through 20-04-2007",

year = "2007",

doi = "10.1109/ICASSP.2007.366678",

language = "English",

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booktitle = "IEEE International Conference on Acoustics, Speech and Signal Processing, 2007. ICASSP 2007.",

publisher = "CASSP",

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Bödvarsson, B, Hansen, LK, Svarer, C & Knudsen, G 2007, NMF on positron emission tomography. in IEEE International Conference on Acoustics, Speech and Signal Processing, 2007. ICASSP 2007.. CASSP, CASSP, 2007 IEEE International Conference on Acoustics, Speech and Signal Processing, Honolulu, Hawaii, United States, 15/04/2007. https://doi.org/10.1109/ICASSP.2007.366678

TY - GEN

T1 - NMF on positron emission tomography

AU - Bödvarsson, Bjarni

AU - Hansen, Lars Kai

AU - Svarer, Claus

AU - Knudsen, Gitte

N1 - Conference code: 32

PY - 2007

Y1 - 2007

N2 - In positron emission tomography, kinetic modelling of brain tracer uptake, metabolism or binding requires knowledge of the cerebral input function. Traditionally, this is achieved with arterial blood sampling in the arm or as shown in (Liptrot, M, et al., 2004) by non-invasive K-means clustering. We propose another method to estimate time-activity curves (TAC) extracted directly from dynamic positron emission tomography (PET) scans by non-negative matrix factorization (NMF). Since the scaling of the basis curves is lost in the NMF the estimated TAC is scaled by a vector alpha which is calculated from the NMF solution. The method is tested on a [18F]-Altanserin tracer ligand data set consisting of 5 healthy subjects. The results from using K-means clustering and NMF are compared to a sampled arterial TAC. The comparison is done by calculating the correlation with the arterial sampled TAC.

AB - In positron emission tomography, kinetic modelling of brain tracer uptake, metabolism or binding requires knowledge of the cerebral input function. Traditionally, this is achieved with arterial blood sampling in the arm or as shown in (Liptrot, M, et al., 2004) by non-invasive K-means clustering. We propose another method to estimate time-activity curves (TAC) extracted directly from dynamic positron emission tomography (PET) scans by non-negative matrix factorization (NMF). Since the scaling of the basis curves is lost in the NMF the estimated TAC is scaled by a vector alpha which is calculated from the NMF solution. The method is tested on a [18F]-Altanserin tracer ligand data set consisting of 5 healthy subjects. The results from using K-means clustering and NMF are compared to a sampled arterial TAC. The comparison is done by calculating the correlation with the arterial sampled TAC.

U2 - 10.1109/ICASSP.2007.366678

DO - 10.1109/ICASSP.2007.366678

M3 - Article in proceedings

SN - 1-4244-0727-3

BT - IEEE International Conference on Acoustics, Speech and Signal Processing, 2007. ICASSP 2007.

PB - CASSP

CY - CASSP

T2 - 2007 IEEE International Conference on Acoustics, Speech and Signal Processing

Y2 - 15 April 2007 through 20 April 2007

ER -

NMF on positron emission tomography

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