TY - JOUR
T1 - Newcastle disease outbreaks in recent years in Western Europe were caused by an old (VI) and a novel genotype (VII)
AU - Lomniczi, B.
AU - Wehmann, E.
AU - Herczeg, J.
AU - Ballagi-Pordany, A.
AU - Kaleta, E.F.
AU - Werner, O.
AU - Meulemans, G.
AU - Jørgensen, Poul Henrik
AU - Mante, A.P.
AU - Gielkens, A.L.J.
AU - Capua, I.
AU - Damoser, J.
PY - 1998
Y1 - 1998
N2 - Newcastle disease virus (NDV) strains, isolated from outbreaks during epizootics between 1992 and 1996 in Western European countries, were compared by restriction enzyme cleavage site mapping of the fusion (F) protein gene between nucleotides 334 and 1682 and by sequence analysis between nucleotides 47 and 435. Both methods revealed that NDV strains responsible for these epizootics belong to two distinct genotypes. Strains derived from sporadic cases in Denmark, Sweden, Switzerland and Austria were classified into genotype VI [6], the same group which caused outbreaks in the Middle East and Greece in the late 1960's and in Hungary in the early 1980's. In contrast, viruses that caused epizootics in Germany, Belgium, The Netherlands, Spain and Italy could be classified into a novel genotype (provisionally termed VII), hitherto undetected in Europe. It is possible that the genotype VII viruses originated in the Far East because they showed a high genetic similarity (97%) to NDV strains isolated from Indonesia in the late 1980's.
AB - Newcastle disease virus (NDV) strains, isolated from outbreaks during epizootics between 1992 and 1996 in Western European countries, were compared by restriction enzyme cleavage site mapping of the fusion (F) protein gene between nucleotides 334 and 1682 and by sequence analysis between nucleotides 47 and 435. Both methods revealed that NDV strains responsible for these epizootics belong to two distinct genotypes. Strains derived from sporadic cases in Denmark, Sweden, Switzerland and Austria were classified into genotype VI [6], the same group which caused outbreaks in the Middle East and Greece in the late 1960's and in Hungary in the early 1980's. In contrast, viruses that caused epizootics in Germany, Belgium, The Netherlands, Spain and Italy could be classified into a novel genotype (provisionally termed VII), hitherto undetected in Europe. It is possible that the genotype VII viruses originated in the Far East because they showed a high genetic similarity (97%) to NDV strains isolated from Indonesia in the late 1980's.
U2 - 10.1007/s007050050267
DO - 10.1007/s007050050267
M3 - Journal article
SN - 0304-8608
VL - 143
SP - 49
EP - 64
JO - Archives of Virology
JF - Archives of Virology
IS - 1
ER -