New polynucleotides, having diagnostic and therapeutic applications - include one or more phosphoro-di:thioate inter-nucleotide linkages

W Brill (Inventor), E Yau (Inventor), John Nielsen (Inventor), M H, CARUTHERS (Inventor), M MA (Inventor)

    Research output: Patent

    Abstract

    Polynucleotides, in which all the internucleotide linkages between individual nucleotide groups in the polynucleotide are phosphorodithioate internucleotide linkages, are new. Also claimed are: (A) polynucleotides which have at least one phosphorodithioate internucleotide linkage in combination with phosphate, phosphorothioate or phosphorothioamidate internucleotide linkages; (B) polynucleotides which have both phosphorodithioate and phosphate internucleotide linkages; (C) oligonucleotides, in protected or unprotected form, which have at least one phosphorodithioate internucleotide linkage; and (D) oligonucleotides, in protected or unprotected form, comprising dinucleosides which have H-phosphonothioate internucleotide linkages.
    Original languageEnglish
    Patent numberUS5750666-A
    Filing date12/05/1998
    CountryUnited States
    Publication statusPublished - 1998

    Bibliographical note

    37 pages

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