New paradigms for metabolic modeling of human cells

Adil Mardinoglu, Jens Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Abnormalities in cellular functions are associated with the progression of human diseases, often resulting in metabolic reprogramming. GEnome-scale metabolic Models (GEMs) have enabled studying global metabolic reprogramming in connection with disease development in a systematic manner. Here we review recent work on reconstruction of GEMs for human cell/tissue types and cancer, and the use of GEMs for identification of metabolic changes occurring in response to disease development. We further discuss how GEMs can be used for the development of efficient therapeutic strategies. Finally, challenges in integration of cell/tissue models for simulation of whole body functions as well as integration of GEMs with other biological networks for generating complete cell/tissue models are presented.
Original languageEnglish
JournalCurrent Opinion in Biotechnology
Volume34
Pages (from-to)91-97
Number of pages7
ISSN0958-1669
DOIs
Publication statusPublished - 2015

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