TY - JOUR
T1 - New naphthyl derivatives from Aspergillus californicus
AU - Guo, Yaojie
AU - Ghidinelli, Simone
AU - de la Cruz, Mercedes
AU - Mackenzie, Thomas A.
AU - Ramos, Maria C.
AU - Sánchez, Pilar
AU - Vicente, Francisca
AU - Genilloud, Olga
AU - Larsen, Thomas O.
PY - 2021
Y1 - 2021
N2 - Two new naphthyl-products calinaphthyltriol A (1) and calinaphthalenone A (2) were isolated from Aspergillus californicus IBT 16748 together with one known compound ophiobolin X (3). Their structures were elucidated by extensive spectroscopic analyses. The absolute configuration of 2 was solved by comparing its optical rotation with data for the known compounds 4, 5, and 6 as well as theoretical calculations. The antibacterial and cytotoxic activities of 1 and 3 were evaluated. Both compounds did not show antibacterial activity (MIC > 96 µg·ml-1) against a few selected clinically relevant Gram positive and Gram negative bacterial strains. However, they showed moderate cytotoxicity against HL-60 cell line with IC50 values of 18 and 24 µg·ml-1, respectively.
AB - Two new naphthyl-products calinaphthyltriol A (1) and calinaphthalenone A (2) were isolated from Aspergillus californicus IBT 16748 together with one known compound ophiobolin X (3). Their structures were elucidated by extensive spectroscopic analyses. The absolute configuration of 2 was solved by comparing its optical rotation with data for the known compounds 4, 5, and 6 as well as theoretical calculations. The antibacterial and cytotoxic activities of 1 and 3 were evaluated. Both compounds did not show antibacterial activity (MIC > 96 µg·ml-1) against a few selected clinically relevant Gram positive and Gram negative bacterial strains. However, they showed moderate cytotoxicity against HL-60 cell line with IC50 values of 18 and 24 µg·ml-1, respectively.
U2 - 10.1038/s41429-020-00372-4
DO - 10.1038/s41429-020-00372-4
M3 - Journal article
C2 - 32999431
SN - 0021-8820
VL - 74
SP - 111
EP - 114
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
ER -