New naphthyl derivatives from Aspergillus californicus

Yaojie Guo, Simone Ghidinelli, Mercedes de la Cruz, Thomas A. Mackenzie, Maria C. Ramos, Pilar Sánchez, Francisca Vicente, Olga Genilloud, Thomas O. Larsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Two new naphthyl-products calinaphthyltriol A (1) and calinaphthalenone A (2) were isolated from Aspergillus californicus IBT 16748 together with one known compound ophiobolin X (3). Their structures were elucidated by extensive spectroscopic analyses. The absolute configuration of 2 was solved by comparing its optical rotation with data for the known compounds 4, 5, and 6 as well as theoretical calculations. The antibacterial and cytotoxic activities of 1 and 3 were evaluated. Both compounds did not show antibacterial activity (MIC > 96 µg·ml-1) against a few selected clinically relevant Gram positive and Gram negative bacterial strains. However, they showed moderate cytotoxicity against HL-60 cell line with IC50 values of 18 and 24 µg·ml-1, respectively.
Original languageEnglish
JournalThe Journal of Antibiotics
Volume74
Pages (from-to)111-114
Number of pages4
ISSN0021-8820
DOIs
Publication statusPublished - 2021

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