New Insights into Adiponectin and Leptin Roles in Chronic Kidney Disease

Susana Coimbra*, Susana Rocha, Maria João Valente, Cristina Catarino, Elsa Bronze-da-Rocha, Luís Belo, Alice Santos-Silva*

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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Abstract

Chronic kidney disease (CKD) is commonly associated with a high burden of comorbidities and poor clinical outcomes. Malnutrition–inflammation–atherosclerosis syndrome is common in the more severe stages of CKD, suggesting a close interplay for these three comorbid conditions. Both malnutrition and obesity are associated with a disturbed adipokine profile and inflammation, contributing to a higher risk of cardiovascular disease (CVD) events. Adiponectin and leptin have important roles in carbohydrate and lipid metabolism, and in the inflammatory process. The effects of adiponectin and leptin alterations in CKD, which are usually increased, and their association with the different comorbidities found in CKD, will be focused on to understand their crosstalk with the risk of CVD events. Nonetheless, although adiponectin and leptin contribute to a higher risk of CVD events, further studies are warranted to fully clarify their roles, especially when different comorbidities exist.
Original languageEnglish
Article number2642
JournalBiomedicines
Volume10
Issue number10
Number of pages19
ISSN2227-9059
DOIs
Publication statusPublished - 2022

Keywords

  • Adiponectin
  • Leptin
  • Chronic kidney disease
  • Cardiovascular disease
  • Inflammation
  • Comorbidities

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