New expanded bed adsorbents for the recovery of DNA

Irini Theodossiou, M. A. Olander, M. Sondergaard, Owen R. T. Thomas

    Research output: Contribution to journalJournal articleResearchpeer-review


    A 20-40 mum pellicular high density (similar to3.7 g cm(-3)) expanded bed material has been designed for the capture of DNA and other large macromolecules. Anion exchangers fashioned out of these supports exhibited dramatically enhanced DNA binding capacities over commercial anion exchange adsorbents (6 mg ml(-1), c.f. similar to 50 mug ml(-1) at 10% breakthrough), due to a combination of small particle and 'fuzzy' surface architecture created through the coupling of polyethylene imine chains.
    Original languageEnglish
    JournalBiotechnology Letters
    Issue number24
    Pages (from-to)1929-1933
    Publication statusPublished - 2000


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