New concepts in antimicrobial resistance in cystic fibrosis respiratory infections

Pavel Drevinek*, Rafael Canton, Helle Krogh Johansen, Lucas Hoffman, Tom Coenye, Pierre Regis Burgel, Jane C. Davies

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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Abstract

In this review, we summarize the main points that were raised and highlighted during the pre-conference meeting to the 17th European Cystic Fibrosis Society Basic Science Conference, held from 30 March to 2 April, 2022 in Albufeira, Portugal. Keynote lectures provided an update on the latest information regarding the phenomenon of antimicrobial resistance (AMR) in cystic fibrosis (CF). Traditional themes such as in vitro antibiotic susceptibility testing and its clinical value, AMR evolution in persistent Pseudomonas aeruginosa infection and the impact of biofilm on AMR were discussed. In addition, the report gives an overview on very recent AMR-related topics that include an ecological view of AMR in CF lung, referred to as resistome, and novel anti-infective approaches in preclinical or early clinical research such as antibiofilm drugs and bacteriophages.

Original languageEnglish
Article number937-945
JournalJournal of Cystic Fibrosis
Volume21
Number of pages9
ISSN1569-1993
DOIs
Publication statusPublished - 2022

Keywords

  • Antimicrobial resistance
  • Antimicrobial strategies
  • Antimicrobial susceptibility testing
  • Biofilm
  • Pathoadaptation
  • Resistome

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