New concepts in antimicrobial resistance in cystic fibrosis respiratory infections

Pavel Drevinek; Rafael Canton; Helle Krogh Johansen; Lucas Hoffman; Tom Coenye; Pierre Regis Burgel; Jane C. Davies

doi:10.1016/j.jcf.2022.10.005

New concepts in antimicrobial resistance in cystic fibrosis respiratory infections

Pavel Drevinek^*, Rafael Canton, Helle Krogh Johansen, Lucas Hoffman, Tom Coenye, Pierre Regis Burgel, Jane C. Davies

^*Corresponding author for this work

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Abstract

In this review, we summarize the main points that were raised and highlighted during the pre-conference meeting to the 17^th European Cystic Fibrosis Society Basic Science Conference, held from 30 March to 2 April, 2022 in Albufeira, Portugal. Keynote lectures provided an update on the latest information regarding the phenomenon of antimicrobial resistance (AMR) in cystic fibrosis (CF). Traditional themes such as in vitro antibiotic susceptibility testing and its clinical value, AMR evolution in persistent Pseudomonas aeruginosa infection and the impact of biofilm on AMR were discussed. In addition, the report gives an overview on very recent AMR-related topics that include an ecological view of AMR in CF lung, referred to as resistome, and novel anti-infective approaches in preclinical or early clinical research such as antibiofilm drugs and bacteriophages.

Original language	English
Article number	937-945
Journal	Journal of Cystic Fibrosis
Volume	21
Number of pages	9
ISSN	1569-1993
DOIs	https://doi.org/10.1016/j.jcf.2022.10.005
Publication status	Published - 2022

Keywords

Antimicrobial resistance
Antimicrobial strategies
Antimicrobial susceptibility testing
Biofilm
Pathoadaptation
Resistome

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title = "New concepts in antimicrobial resistance in cystic fibrosis respiratory infections",

abstract = "In this review, we summarize the main points that were raised and highlighted during the pre-conference meeting to the 17th European Cystic Fibrosis Society Basic Science Conference, held from 30 March to 2 April, 2022 in Albufeira, Portugal. Keynote lectures provided an update on the latest information regarding the phenomenon of antimicrobial resistance (AMR) in cystic fibrosis (CF). Traditional themes such as in vitro antibiotic susceptibility testing and its clinical value, AMR evolution in persistent Pseudomonas aeruginosa infection and the impact of biofilm on AMR were discussed. In addition, the report gives an overview on very recent AMR-related topics that include an ecological view of AMR in CF lung, referred to as resistome, and novel anti-infective approaches in preclinical or early clinical research such as antibiofilm drugs and bacteriophages.",

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AU - Drevinek, Pavel

AU - Canton, Rafael

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AU - Hoffman, Lucas

AU - Coenye, Tom

AU - Burgel, Pierre Regis

AU - Davies, Jane C.

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KW - Antimicrobial resistance

KW - Antimicrobial strategies

KW - Antimicrobial susceptibility testing

KW - Biofilm

KW - Pathoadaptation

KW - Resistome

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New concepts in antimicrobial resistance in cystic fibrosis respiratory infections

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Keywords

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