New attenuation correction for the HRRT using transmission scatter correction and total variation regularization

Merence Sibomana, Sune Høgild Keller, Claus Svarer, Oline Vinter Olesen, Flemming Andersen, Søren Holm, Liselotte Højgaard

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

    Abstract

    In the standard software for the Siemens HRRT PET scanner the most commonly used segmentation in the μ-map reconstruction for human brain scans is MAP-TR. Problems with bias in the lower cerebellum and pons in HRRT brain images have been reported. The main source of the problem is poor bone / soft tissue segmentation in these regions and the lack of scatter correction in the μ-map reconstruction. In this paper we describe and validate the new TXTV segmentation method (included in the HRRT_U 1.0 and 1.1 user software) aimed at solving the bias problem. Its improvements fall in two parts: Firstly, it introduces the use of scatter correction, and secondly, it uses a simple threshold in combination with nonlinear total variation μ-map filtering. To validate the new transmission μ-map reconstruction with scatter correction and TXTV segmentation, we compared the average activity in 50 RoIs average on emission images reconstructed with the new TXTV and old MAP-TR μ-maps to images reconstructed with co-registered CT-based μ-maps on four 18F FDG scans. The CT μ-maps is considered a gold standard. The comparison show a significant decrease in the bias in cerebellum and pons, and a better agreement between images reconstructed with the new method and CT-based μ-maps.
    Original languageEnglish
    Title of host publicationIEEE Nuclear Science Symposium Conference Record (NSS/MIC), 2009
    PublisherIEEE
    Publication date2009
    ISBN (Print)978-1-4244-3961-4
    DOIs
    Publication statusPublished - 2009
    Event2009 IEEE Nuclear Science Symposium and Medical Imaging Conference - Orlando, FL, United States
    Duration: 25 Oct 200931 Oct 2009

    Conference

    Conference2009 IEEE Nuclear Science Symposium and Medical Imaging Conference
    CountryUnited States
    CityOrlando, FL
    Period25/10/200931/10/2009

    Keywords

    • scatter correction
    • attenuation correction
    • reconstruction
    • positron emission tomography

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