Neutral, anionic, cationic, and zwitterionic diblock copolymers featuring poly(2-methoxyethyl acrylate) hydrophobic segments

Irakli Javakhishvili, Katja Jankova Atanasova, Søren Hvilsted

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Amphiphilic diblock copolymers incorporating hydrophobic poly(2-methoxyethyl acrylate) (PMEA) and hydrophilic neutral poly(ethylene glycol) monomethyl ether (mPEG), anionic poly(acrylic acid) (PAA) and poly(methacrylic acid) (PMAA), cationic poly(2-dimethylaminoethyl methacrylate) (PDMAEMA), and zwitterionic poly(3-(N-(2-methacryloyloxyethyl)-N,N- dimethylammonio)propane sulfonate) (PDMAPS) blocks are constructed. mPEG, poly(tert-butyl acrylate) (PtBA), and poly(tert-butyl methacrylate) (PtBMA) macroinitiators are chain extended with 2-methoxyethyl acrylate (MEA) employing copper-mediated atom transfer radical polymerization (ATRP) garnishing well-defined diblock copolymers with narrow polydispersities (1.11-1.30). Selective cleavage of the tert-butyl esters affords PAA-b-PMEA and PMAA-b-PMEA. ATRP of 2-dimethylaminoethyl methacrylate (DMAEMA) from the PMEA macroinitiator results in PMEA-b-PDMAEMA while the betainisation of the latter provides zwitterionic diblock amphiphile PMEA-b-PDMAPS. Inspection of these macromolecular architectures by NMR spectroscopy and size exclusion chromatography (SEC) confirms a fairly high degree of control over the reactions emphasizing flexibility and precision of the approach. © 2013 The Royal Society of Chemistry.
Original languageEnglish
JournalPolymer Chemistry
Issue number3
Pages (from-to)662-668
Publication statusPublished - 2013


  • Atom transfer radical polymerization
  • Carboxylic acids
  • Ethers
  • Hydrogels
  • Hydrophobicity
  • Motion Picture Experts Group standards
  • Nuclear magnetic resonance spectroscopy
  • Polyethylene glycols
  • Propane
  • Block copolymers

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