Network Medicine Strikes a Blow against Breast Cancer

Janine Terra Erler; Rune Linding

doi:10.1016/j.cell.2012.04.014

Network Medicine Strikes a Blow against Breast Cancer

Janine Terra Erler
, Rune Linding

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

Original language	English
Journal	Cell
Volume	149
Issue number	4
Pages (from-to)	731-733
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2012.04.014
Publication status	Published - 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.cell.2012.04.014

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title = "Network Medicine Strikes a Blow against Breast Cancer",

abstract = "Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.",

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AU - Erler, Janine Terra

AU - Linding, Rune

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AB - Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

U2 - 10.1016/j.cell.2012.04.014

DO - 10.1016/j.cell.2012.04.014

M3 - Journal article

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SN - 0092-8674

VL - 149

SP - 731

EP - 733

JO - Cell

JF - Cell

IS - 4

ER -

Network Medicine Strikes a Blow against Breast Cancer

Abstract

UN SDGs

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