Network Medicine Strikes a Blow against Breast Cancer

Janine Terra Erler; Rune Linding

doi:10.1016/j.cell.2012.04.014

Network Medicine Strikes a Blow against Breast Cancer

Janine Terra Erler, Rune Linding

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

Original language	English
Journal	Cell
Volume	149
Issue number	4
Pages (from-to)	731-733
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2012.04.014
Publication status	Published - 2012

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abstract = "Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.",

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Network Medicine Strikes a Blow against Breast Cancer

Abstract

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