Network Medicine Strikes a Blow against Breast Cancer

Janine Terra Erler, Rune Linding

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.
    Original languageEnglish
    JournalCell
    Volume149
    Issue number4
    Pages (from-to)731-733
    ISSN0092-8674
    DOIs
    Publication statusPublished - 2012

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