NESbase version 1.0: a database of nuclear export signals

T. la Cour; Ramneek Gupta; Krzysztof Rapacki; K. Skriver; F.M. Poulsen; Søren Brunak

NESbase version 1.0: a database of nuclear export signals

T. la Cour, Ramneek Gupta, Krzysztof Rapacki, K. Skriver, F.M. Poulsen, Søren Brunak

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Protein export from the nucleus is often mediated by a Leucine-rich Nuclear Export Signal (NES). NESbase is a database of experimentally validated Leucine-rich NESs curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each NESbase entry contains information of whether NES was shown to be necessary and/or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. The compiled information was used to make a sequence logo of the Leucine-rich NESs, displaying the conservation of amino acids within a window of 25 residues. Surprisingly, only 36% of the sequences used for the logo fit the widely accepted NES consensus L-x( 2,3) -[ LIVFM] x( 2,3) - L-x-[ LI]. The database is available online at http: / / www. cbs. dtu. dk/ databases/ NESbase/.

Original language	English
Journal	Nucleic Acids Research
Volume	31
Issue number	1
Pages (from-to)	393-396
ISSN	0305-1048
Publication status	Published - 2003

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title = "NESbase version 1.0: a database of nuclear export signals",

abstract = "Protein export from the nucleus is often mediated by a Leucine-rich Nuclear Export Signal (NES). NESbase is a database of experimentally validated Leucine-rich NESs curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each NESbase entry contains information of whether NES was shown to be necessary and/or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. The compiled information was used to make a sequence logo of the Leucine-rich NESs, displaying the conservation of amino acids within a window of 25 residues. Surprisingly, only 36\% of the sequences used for the logo fit the widely accepted NES consensus L-x( 2,3) -[ LIVFM] x( 2,3) - L-x-[ LI]. The database is available online at http: / / www. cbs. dtu. dk/ databases/ NESbase/.",

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year = "2003",

language = "English",

volume = "31",

pages = "393--396",

journal = "Nucleic Acids Research",

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TY - JOUR

T1 - NESbase version 1.0: a database of nuclear export signals

AU - la Cour, T.

AU - Gupta, Ramneek

AU - Rapacki, Krzysztof

AU - Skriver, K.

AU - Poulsen, F.M.

AU - Brunak, Søren

PY - 2003

Y1 - 2003

N2 - Protein export from the nucleus is often mediated by a Leucine-rich Nuclear Export Signal (NES). NESbase is a database of experimentally validated Leucine-rich NESs curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each NESbase entry contains information of whether NES was shown to be necessary and/or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. The compiled information was used to make a sequence logo of the Leucine-rich NESs, displaying the conservation of amino acids within a window of 25 residues. Surprisingly, only 36% of the sequences used for the logo fit the widely accepted NES consensus L-x( 2,3) -[ LIVFM] x( 2,3) - L-x-[ LI]. The database is available online at http: / / www. cbs. dtu. dk/ databases/ NESbase/.

AB - Protein export from the nucleus is often mediated by a Leucine-rich Nuclear Export Signal (NES). NESbase is a database of experimentally validated Leucine-rich NESs curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each NESbase entry contains information of whether NES was shown to be necessary and/or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. The compiled information was used to make a sequence logo of the Leucine-rich NESs, displaying the conservation of amino acids within a window of 25 residues. Surprisingly, only 36% of the sequences used for the logo fit the widely accepted NES consensus L-x( 2,3) -[ LIVFM] x( 2,3) - L-x-[ LI]. The database is available online at http: / / www. cbs. dtu. dk/ databases/ NESbase/.

M3 - Journal article

SN - 0305-1048

VL - 31

SP - 393

EP - 396

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 1

ER -

NESbase version 1.0: a database of nuclear export signals

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