NESbase version 1.0: a database of nuclear export signals

T. la Cour, Ramneek Gupta, Krzysztof Rapacki, K. Skriver, F.M. Poulsen, Søren Brunak

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Protein export from the nucleus is often mediated by a Leucine-rich Nuclear Export Signal (NES). NESbase is a database of experimentally validated Leucine-rich NESs curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each NESbase entry contains information of whether NES was shown to be necessary and/or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. The compiled information was used to make a sequence logo of the Leucine-rich NESs, displaying the conservation of amino acids within a window of 25 residues. Surprisingly, only 36% of the sequences used for the logo fit the widely accepted NES consensus L-x( 2,3) -[ LIVFM] x( 2,3) - L-x-[ LI]. The database is available online at http: / / www. cbs. dtu. dk/ databases/ NESbase/.
    Original languageEnglish
    JournalNucleic acids research
    Volume31
    Issue number1
    Pages (from-to)393-396
    ISSN0305-1048
    Publication statusPublished - 2003

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