Near-Field Exposures and Human Health Impacts for Organic Chemicals in Interior Paints: A High-Throughput Screening

Lei Huang, Nicolò Aurisano, Peter Fantke, Amal Dissanayake, L.G.L.M. Edirisinghe, Olivier Jolliet*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

32 Downloads (Pure)


Interior paints contain organic chemicals that might be harmful to painters and building residents. This study aims to develop a high-throughput approach to screen near-field human exposures and health impacts related to organic chemicals in interior paints. We developed mass balance models for both water- and solvent-based paints, predicting emissions during wet and dry phases. We then screened exposures and risks, focusing on Sri Lanka where residential houses are frequently repainted. These models accurately predict paint drying time and indoor air concentrations of organic chemicals. Exposures of both painter and household resident were estimated for 65 organic chemicals in water-based and 26 in solvent-based paints, considering 12 solvents. Chemicals of concerns (CoCs) were identified, and maximum acceptable chemical contents (MACs) were calculated. Water-based paints generally pose lower health risks than solvent-based paints but might contain biocides of high concern. The total human health impact of one painting event on all household adults ranges from 1.5×10-3 to 2.1×10-2 DALYs for solvent-based paints, and from 4.1×10-4 to 9.5×10-3 DALYs for water-based paints. The present approach is a promising way to support the formulation of safer paint, and is integrated in USEtox3 for use in life cycle assessment, chemical substitution and risk screening.
Original languageEnglish
Article number133145
JournalJournal of Hazardous Materials
Number of pages32
Publication statusPublished - 2024


  • Exposure modeling
  • USEtox
  • Consumer products
  • Biocides
  • MAximum chemical Contents (MAC)


Dive into the research topics of 'Near-Field Exposures and Human Health Impacts for Organic Chemicals in Interior Paints: A High-Throughput Screening'. Together they form a unique fingerprint.

Cite this