Abstract
The article discusses the role of allogeneic hematopoietic cell transplantation (HCT) in treating hematologic malignancies. It says that HCT represents a potentially curative treatment for several hematologic malignancies. Meanwhile, the curative principle in allogeneic HCT with NMA conditioning is solely related to the graft-versus-leukemia (GVL) effect, and several lines of evidence strongly suggest that donor T cells are the main effectors.
| Original language | English |
|---|---|
| Journal | Leukemia |
| Volume | 22 |
| Issue number | 10 |
| Pages (from-to) | 1948-1951 |
| Number of pages | 4 |
| ISSN | 0887-6924 |
| DOIs | |
| Publication status | Published - 2008 |
| Externally published | Yes |
Keywords
- Hematology
- Cancer Research
- Anesthesiology and Pain Medicine
- HLA A2 antigen
- major histocompatibility antigen
- major histocompatibility antigen HY
- unclassified drug
- article
- CD8+ T lymphocyte
- cellular immunity
- chronic lymphatic leukemia
- clinical article
- clonal variation
- coculture
- controlled study
- female
- fluorescence activated cell sorting
- genotype
- graft recipient
- graft versus host reaction
- hematopoietic stem cell transplantation
- HLA matching
- human
- human cell
- major histocompatibility complex
- male
- peripheral blood mononuclear cell
- priority journal
- sibling
- T lymphocyte
- CD8-Positive T-Lymphocytes
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Testing
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Minor Histocompatibility Antigens
- T-Lymphocytes
- ONCOLOGY
- HEMATOLOGY
- VERSUS-HOST-DISEASE
- IMMUNOTHERAPY
- PREGNANCY
- CANCER
- HA-1
- TRANSPLANTATION of organs, tissues, etc.
