Natural T-cell responses against minor histocompatibility antigen (mHag) HY following HLA-matched hematopoietic cell transplantation: what are the requirements for a 'good' mHag?

T. Kollgaard, Sine Reker Hadrup, S. L. Petersen, T. N. Masmas, M. H. Andersen, E. Spierings, L. Vindeløv, P. thor Straten

Research output: Contribution to journalLetterpeer-review

Abstract

The article discusses the role of allogeneic hematopoietic cell transplantation (HCT) in treating hematologic malignancies. It says that HCT represents a potentially curative treatment for several hematologic malignancies. Meanwhile, the curative principle in allogeneic HCT with NMA conditioning is solely related to the graft-versus-leukemia (GVL) effect, and several lines of evidence strongly suggest that donor T cells are the main effectors.
Original languageEnglish
JournalLeukemia
Volume22
Issue number10
Pages (from-to)1948-1951
Number of pages4
ISSN0887-6924
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine
  • HLA A2 antigen
  • major histocompatibility antigen
  • major histocompatibility antigen HY
  • unclassified drug
  • article
  • CD8+ T lymphocyte
  • cellular immunity
  • chronic lymphatic leukemia
  • clinical article
  • clonal variation
  • coculture
  • controlled study
  • female
  • fluorescence activated cell sorting
  • genotype
  • graft recipient
  • graft versus host reaction
  • hematopoietic stem cell transplantation
  • HLA matching
  • human
  • human cell
  • major histocompatibility complex
  • male
  • peripheral blood mononuclear cell
  • priority journal
  • sibling
  • T lymphocyte
  • CD8-Positive T-Lymphocytes
  • Hematopoietic Stem Cell Transplantation
  • Histocompatibility Testing
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Minor Histocompatibility Antigens
  • T-Lymphocytes
  • ONCOLOGY
  • HEMATOLOGY
  • VERSUS-HOST-DISEASE
  • IMMUNOTHERAPY
  • PREGNANCY
  • CANCER
  • HA-1
  • TRANSPLANTATION of organs, tissues, etc.

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