Nanoscaled biological gated field effect transistors for cytogenetic analysis

Dorota Kwasny; Maria Dimaki; Karsten Brandt Andersen; Azeem Zulfiqar; Z. Tümer; Winnie Edith Svendsen

doi:10.1109/NEMS.2014.6908775

Nanoscaled biological gated field effect transistors for cytogenetic analysis

Dorota Kwasny, Maria Dimaki, Karsten Brandt Andersen, Azeem Zulfiqar, Z. Tümer, Winnie Edith Svendsen

Technical University of Denmark

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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Abstract

Cytogenetic analysis is the study of chromosome structure and function, and is often used in cancer diagnosis, as many chromosome abnormalities are linked to the onset of cancer. A novel label free detection method for chromosomal translocation analysis using nanoscaled field effect transistors (FET) is presented here. The FET is gated by the hybridization of the target DNA on the semiconducting nanowire. The results show an extreme sensitivity to the hybridization process, so that the hybridization and dehybridisation can be followed in real time. The nanoscaled FET is made of polysilicon using standard UV lithography enabling batch processing of the sensors.

Original language	English
Title of host publication	Proceedings of the 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Number of pages	5
Publisher	IEEE
Publication date	2014
Pages	130-134
ISBN (Electronic)	978-1-4799-4726-3
DOIs	https://doi.org/10.1109/NEMS.2014.6908775
Publication status	Published - 2014
Event	9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems - Hyatt Regency Waikiki Beach Resort and Spa, Honolulu, United States Duration: 13 Apr 2014 → 16 Apr 2014 Conference number: 9

Conference

Conference	9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Number	9
Location	Hyatt Regency Waikiki Beach Resort and Spa
Country/Territory	United States
City	Honolulu
Period	13/04/2014 → 16/04/2014

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10.1109/NEMS.2014.6908775

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title = "Nanoscaled biological gated field effect transistors for cytogenetic analysis",

abstract = "Cytogenetic analysis is the study of chromosome structure and function, and is often used in cancer diagnosis, as many chromosome abnormalities are linked to the onset of cancer. A novel label free detection method for chromosomal translocation analysis using nanoscaled field effect transistors (FET) is presented here. The FET is gated by the hybridization of the target DNA on the semiconducting nanowire. The results show an extreme sensitivity to the hybridization process, so that the hybridization and dehybridisation can be followed in real time. The nanoscaled FET is made of polysilicon using standard UV lithography enabling batch processing of the sensors.",

author = "Dorota Kwasny and Maria Dimaki and Andersen, {Karsten Brandt} and Azeem Zulfiqar and Z. T{\"u}mer and Svendsen, {Winnie Edith}",

year = "2014",

doi = "10.1109/NEMS.2014.6908775",

language = "English",

pages = "130--134",

booktitle = "Proceedings of the 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems",

publisher = "IEEE",

address = "United States",

note = "9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS2014 ; Conference date: 13-04-2014 Through 16-04-2014",

}

Kwasny, D, Dimaki, M, Andersen, KB, Zulfiqar, A, Tümer, Z & Svendsen, WE 2014, Nanoscaled biological gated field effect transistors for cytogenetic analysis. in Proceedings of the 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, pp. 130-134, 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Honolulu, United States, 13/04/2014. https://doi.org/10.1109/NEMS.2014.6908775

Nanoscaled biological gated field effect transistors for cytogenetic analysis. / Kwasny, Dorota; Dimaki, Maria; Andersen, Karsten Brandt et al.
Proceedings of the 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2014. p. 130-134.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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T1 - Nanoscaled biological gated field effect transistors for cytogenetic analysis

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AU - Dimaki, Maria

AU - Andersen, Karsten Brandt

AU - Zulfiqar, Azeem

AU - Tümer, Z.

AU - Svendsen, Winnie Edith

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AB - Cytogenetic analysis is the study of chromosome structure and function, and is often used in cancer diagnosis, as many chromosome abnormalities are linked to the onset of cancer. A novel label free detection method for chromosomal translocation analysis using nanoscaled field effect transistors (FET) is presented here. The FET is gated by the hybridization of the target DNA on the semiconducting nanowire. The results show an extreme sensitivity to the hybridization process, so that the hybridization and dehybridisation can be followed in real time. The nanoscaled FET is made of polysilicon using standard UV lithography enabling batch processing of the sensors.

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T2 - 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Y2 - 13 April 2014 through 16 April 2014

ER -

Nanoscaled biological gated field effect transistors for cytogenetic analysis

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