Nanoscaled biological gated field effect transistors for cytogenetic analysis

Dorota Kwasny, Maria Dimaki, Karsten Brandt Andersen, Azeem Zulfiqar, Z. Tümer, Winnie Edith Svendsen

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    Abstract

    Cytogenetic analysis is the study of chromosome structure and function, and is often used in cancer diagnosis, as many chromosome abnormalities are linked to the onset of cancer. A novel label free detection method for chromosomal translocation analysis using nanoscaled field effect transistors (FET) is presented here. The FET is gated by the hybridization of the target DNA on the semiconducting nanowire. The results show an extreme sensitivity to the hybridization process, so that the hybridization and dehybridisation can be followed in real time. The nanoscaled FET is made of polysilicon using standard UV lithography enabling batch processing of the sensors.
    Original languageEnglish
    Title of host publicationProceedings of the 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
    Number of pages5
    PublisherIEEE
    Publication date2014
    Pages130-134
    ISBN (Electronic)978-1-4799-4726-3
    DOIs
    Publication statusPublished - 2014
    Event9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems - Hyatt Regency Waikiki Beach Resort and Spa, Honolulu, United States
    Duration: 13 Apr 201416 Apr 2014
    Conference number: 9

    Conference

    Conference9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
    Number9
    LocationHyatt Regency Waikiki Beach Resort and Spa
    CountryUnited States
    CityHonolulu
    Period13/04/201416/04/2014

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