Nanoscale detection of metal-labeled copolymers in patchy polymersomes

Lorena Ruiz-Perez, Peter Jeppe Madsen, Efrosyni Themistou, Jens Gaitzsch, Lea Messager, Steven P. Armes, Giuseppe Battaglia

Research output: Contribution to journalJournal articleResearchpeer-review


We report the synthesis of polymersome-forming block copolymers using two different synthetic routes based on Atom Transfer Radical Polymerization (ATRP) and Reversible Addition Fragmentation chain Transfer (RAFT) polymerization, respectively. Functionalization with 1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA) allowed the block copolymer chains to be labelled with electron-dense metal ions (e.g. indium). The resulting metal-conjugated copolymers can be visualized by transmission electron microscopy with single chain resolution, hence enabling the study of polymer/polymer immiscibility and phase separation on the nano-scale.
Original languageEnglish
JournalPolymer Chemistry
Issue number11
Pages (from-to)2065-2068
Number of pages4
Publication statusPublished - 2015
Externally publishedYes


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