Nanoscale detection of metal-labeled copolymers in patchy polymersomes

Lorena Ruiz-Perez; Peter Jeppe Madsen; Efrosyni Themistou; Jens Gaitzsch; Lea Messager; Steven P. Armes; Giuseppe Battaglia

doi:10.1039/c4py01508h

Nanoscale detection of metal-labeled copolymers in patchy polymersomes

Lorena Ruiz-Perez, Peter Jeppe Madsen, Efrosyni Themistou, Jens Gaitzsch, Lea Messager, Steven P. Armes, Giuseppe Battaglia

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We report the synthesis of polymersome-forming block copolymers using two different synthetic routes based on Atom Transfer Radical Polymerization (ATRP) and Reversible Addition Fragmentation chain Transfer (RAFT) polymerization, respectively. Functionalization with 1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA) allowed the block copolymer chains to be labelled with electron-dense metal ions (e.g. indium). The resulting metal-conjugated copolymers can be visualized by transmission electron microscopy with single chain resolution, hence enabling the study of polymer/polymer immiscibility and phase separation on the nano-scale.

Original language	English
Journal	Polymer Chemistry
Volume	6
Issue number	11
Pages (from-to)	2065-2068
Number of pages	4
ISSN	1759-9954
DOIs	https://doi.org/10.1039/c4py01508h
Publication status	Published - 2015
Externally published	Yes

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title = "Nanoscale detection of metal-labeled copolymers in patchy polymersomes",

abstract = "We report the synthesis of polymersome-forming block copolymers using two different synthetic routes based on Atom Transfer Radical Polymerization (ATRP) and Reversible Addition Fragmentation chain Transfer (RAFT) polymerization, respectively. Functionalization with 1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA) allowed the block copolymer chains to be labelled with electron-dense metal ions (e.g. indium). The resulting metal-conjugated copolymers can be visualized by transmission electron microscopy with single chain resolution, hence enabling the study of polymer/polymer immiscibility and phase separation on the nano-scale.",

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year = "2015",

doi = "10.1039/c4py01508h",

language = "English",

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journal = "Polymer Chemistry",

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T1 - Nanoscale detection of metal-labeled copolymers in patchy polymersomes

AU - Ruiz-Perez, Lorena

AU - Jeppe Madsen, Peter

AU - Themistou, Efrosyni

AU - Gaitzsch, Jens

AU - Messager, Lea

AU - Armes, Steven P.

AU - Battaglia, Giuseppe

PY - 2015

Y1 - 2015

N2 - We report the synthesis of polymersome-forming block copolymers using two different synthetic routes based on Atom Transfer Radical Polymerization (ATRP) and Reversible Addition Fragmentation chain Transfer (RAFT) polymerization, respectively. Functionalization with 1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA) allowed the block copolymer chains to be labelled with electron-dense metal ions (e.g. indium). The resulting metal-conjugated copolymers can be visualized by transmission electron microscopy with single chain resolution, hence enabling the study of polymer/polymer immiscibility and phase separation on the nano-scale.

AB - We report the synthesis of polymersome-forming block copolymers using two different synthetic routes based on Atom Transfer Radical Polymerization (ATRP) and Reversible Addition Fragmentation chain Transfer (RAFT) polymerization, respectively. Functionalization with 1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA) allowed the block copolymer chains to be labelled with electron-dense metal ions (e.g. indium). The resulting metal-conjugated copolymers can be visualized by transmission electron microscopy with single chain resolution, hence enabling the study of polymer/polymer immiscibility and phase separation on the nano-scale.

U2 - 10.1039/c4py01508h

DO - 10.1039/c4py01508h

M3 - Journal article

SN - 1759-9954

VL - 6

SP - 2065

EP - 2068

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 11

ER -

Nanoscale detection of metal-labeled copolymers in patchy polymersomes

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