Mechanically robust tablets of nanoporous magnesium aluminometasilicate with high surface area and porosity can be loaded with a variety of organic and inorganic reagents and catalysts. The scope of this novel dosing methodology is demonstrated through the evaluation of 14 diverse organic reactions, including Mitsunobu, Suzuki, and bromination reactions.
Ruhland, T., Nielsen, S. D., Holm, P., & Christensen, C. H. (2007). Nanoporous magnesium aluminometasilicate tablets for precise, controlled, and continuous dosing of chemical reagents and catalysts: Applications in parallel solution-phase synthesis. Journal of Combinatorial Chemistry, 9(2), 301-305. https://doi.org/10.1021/cc060089q