Nanomedicines for endothelial disorders

Bomy Lee Chung, Michael J. Toth, Nazila Kamaly, Yoshitaka J. Sei, Jacob Becraft, Willem J. M. Mulder, Zahi A. Fayad, Omid C. Farokhzad, YongTae Kim, Robert Langer

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine – the application of nanotechnology to healthcare – presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.
Original languageEnglish
JournalNano Today
Volume10
Issue number6
Pages (from-to)759–776
ISSN1748-0132
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Endothelium
  • Nanomedicine
  • Endothelial disorder
  • Diabetes

Cite this

Lee Chung, B., Toth, M. J., Kamaly, N., Sei, Y. J., Becraft, J., Mulder, W. J. M., Fayad, Z. A., Farokhzad, O. C., Kim, Y., & Langer, R. (2015). Nanomedicines for endothelial disorders. Nano Today, 10(6), 759–776. http://dx.doi.org/10.1016/j.nantod.2015.11.009