Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

Maksymilian Kurek, Matthias Carnoy, Peter Emil Larsen, Line Hagner Nielsen, Ole Hansen, Thomas Rades, Silvan Schmid, Anja Boisen

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Abstract

Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.
Original languageEnglish
JournalAngewandte Chemie International Edition
Volume56
Pages (from-to)3901-3905
ISSN1433-7851
DOIs
Publication statusPublished - 2017

Keywords

  • IR spectroscopy
  • crystallization
  • nanomechanics
  • nanoparticles

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