Nanomaterial-based functional scaffolds for amperometric sensing of bioanalytes

Ramendra Sundar Dey, Raj Kumar Bera, C.R. Raj

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Functional nanomaterials have emerged as promising candidates in the development of an amperometric sensing platform for the detection and quantification of bioanalytes. The remarkable characteristics of nanomaterials based on metal and metal oxide nanoparticles, carbon nanotubes, and graphene ensure enhanced performance of the sensors in terms of sensitivity, selectivity, detection limit, response time, and multiplexing capability. The electrocatalytic properties of these functional materials can be combined with the biocatalytic activity of redox enzymes to develop integrated biosensing platforms. Highly sensitive and stable miniaturized amperometric sensors have been developed by integrating the nanomaterials and biocatalyst with the transducers. This review provides an update on recent progress in the development of amperometric sensors/biosensors using functional nanomaterials for the sensing of clinically important metabolites such as glucose, cholesterol, lactate, and glutamate, immunosensing of cancer biomarkers, and genosensing.
Original languageEnglish
JournalAnalytical and Bioanalytical Chemistry
Volume405
Pages (from-to)3431–3448
ISSN1618-2642
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Amperometric biosensors
  • Functional nanomaterials
  • Graphene
  • Carbon nanotubes
  • Metal and metal oxide nanoparticles
  • Clinical metabolites
  • Immunosensors
  • Cancer biomarkers
  • DNA
  • Genosensors

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