Nanofluidic Devices with Two Pores in Series for Resistive-Pulse Sensing of Single Virus Capsids

Zachary D. Harms, Klaus Bo Mogensen, Pedro André Rodrigues de Sousa Nunes, Kaimeng Zhou, Brett W. Hildenbrand, Indranil Mitra, Zhenning Tan, Adam Zlotnick, Jörg Peter Kutter, Stephen C. Jacobson

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    We report fabrication and characterization of nanochannel devices with two nanopores in series for resistive-pulse sensing of hepatitis B virus (HBV) capsids. The nanochannel and two pores are patterned by electron beam lithography between two microchannels and etched by reactive ion etching. The two nanopores are 50-nm wide, 50-nm deep, and 40-nm long and are spaced 2.0-μm apart. The nanochannel that brackets the two pores is 20 wider (1 μm) to reduce the electrical resistance adjacent to the two pores and to ensure the current returns to its baseline value between resistive-pulse events. Average pulse amplitudes differ by
    Original languageEnglish
    JournalAnalytical Chemistry
    Volume83
    Pages (from-to)9573-9578
    ISSN0003-2700
    DOIs
    Publication statusPublished - 2011

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