Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders

Itsasne Erezuma, Tatiane Eufrasio-da-Silva, Nasim Golafshan, Kaivalya Deo, Yogendra Kumar Mishra, Miguel Castilho, Akhilesh K. Gaharwar, Sander Leeuwenburgh, Alireza Dolatshahi-Pirouz, Gorka Orive*

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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Nanoclay-reinforced biomaterials have sparked a new avenue in advanced healthcare materials that can potentially revolutionize treatment of musculoskeletal defects. Native tissues display many important chemical, mechanical, biological, and physical properties that engineered biomaterials need to mimic for optimal tissue integration and regeneration. However, it is time-consuming and difficult to endow such combinatorial properties on materials via feasible and nontoxic procedures. Fortunately, a number of nanomaterials such as graphene, carbon nanotubes, MXenes, and nanoclays already display a plethora of material properties that can be transferred to biomaterials through a simple incorporation procedure. In this direction, the members of the nanoclay family are easy to functionalize chemically, they can significantly reinforce the mechanical performance of biomaterials, and can provide bioactive properties by ionic dissolution products to upregulate cartilage and bone tissue formation. For this reason, nanoclays can become a key component for future orthopedic biomaterials. In this review, we specifically focus on the rapidly decreasing gap between clinic and laboratory by highlighting their application in a number of promising in vivo studies.

Original languageEnglish
Article number2100217
JournalAdvanced Healthcare Materials
Issue number16
Number of pages21
Publication statusPublished - 2021


  • Halloysite nanotubes
  • Hydrogels
  • Nanoclay
  • Nanomaterials
  • Nanosilicate
  • Tissue engineering


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