Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy

F Collier, A L Ponsonby, M O'Hely, M L K Tang, R Saffery, J Molloy, L E Gray, S Ranganathan, D Burgner, Katrina J Allen, S Brix, P Vuillermin*, BIS Investigator Group

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequent allergic disease. However longitudinal studies, that account for relevant perinatal factors, are required. The aim of this study was to investigate the relationship between perinatal factors, naïve Treg (nTreg) over the first postnatal year, and development of food allergy. In a birth cohort (n=1074), the proportion of nTreg in the CD4+ T-cell compartment was measured by flow cytometry at birth (n=463), six (n=600) and twelve (n=675) months. IgE-mediated food allergy was determined by food challenge at one year. Associations between perinatal factors (gestation, labour, sex, birth size), nTreg at each time point and food allergy at 1 year were examined by linear regression. A higher proportion of nTreg at birth, larger birth size and male sex were each associated with higher nTreg in infancy. Exposure to labour, as compared to delivery by pre-labour Caesarean section, was associated with a transient decrease nTreg. Infants that developed food allergy had decreased nTreg at birth, and the labour-associated decrease in nTreg at birth was more evident among infants with subsequent food allergy. Mode of birth was not associated with risk of food allergy and there was no evidence that nTreg at either six or twelve months were related to food allergy. The proportion of nTreg at birth is a major determinant of the proportion present throughout infancy, highlighting the importance of prenatal immune development. Exposure to the inflammatory stimulus of labour appears to reveal differences in immune function among infants at risk of food allergy. This article is protected by copyright. All rights reserved.
Original languageEnglish
JournalAllergy
Volume74
Issue number9
Pages (from-to)1760-1768
Number of pages8
ISSN0105-4538
DOIs
Publication statusPublished - 2019

Keywords

  • Food allergy
  • Naïve regulatory T cells
  • Perinatal factors

Cite this

Collier, F., Ponsonby, A. L., O'Hely, M., Tang, M. L. K., Saffery, R., Molloy, J., ... Investigator Group, BIS. (2019). Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy. Allergy, 74(9), 1760-1768. https://doi.org/10.1111/all.13822
Collier, F ; Ponsonby, A L ; O'Hely, M ; Tang, M L K ; Saffery, R ; Molloy, J ; Gray, L E ; Ranganathan, S ; Burgner, D ; Allen, Katrina J ; Brix, S ; Vuillermin, P ; Investigator Group, BIS. / Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy. In: Allergy. 2019 ; Vol. 74, No. 9. pp. 1760-1768.
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abstract = "In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequent allergic disease. However longitudinal studies, that account for relevant perinatal factors, are required. The aim of this study was to investigate the relationship between perinatal factors, na{\"i}ve Treg (nTreg) over the first postnatal year, and development of food allergy. In a birth cohort (n=1074), the proportion of nTreg in the CD4+ T-cell compartment was measured by flow cytometry at birth (n=463), six (n=600) and twelve (n=675) months. IgE-mediated food allergy was determined by food challenge at one year. Associations between perinatal factors (gestation, labour, sex, birth size), nTreg at each time point and food allergy at 1 year were examined by linear regression. A higher proportion of nTreg at birth, larger birth size and male sex were each associated with higher nTreg in infancy. Exposure to labour, as compared to delivery by pre-labour Caesarean section, was associated with a transient decrease nTreg. Infants that developed food allergy had decreased nTreg at birth, and the labour-associated decrease in nTreg at birth was more evident among infants with subsequent food allergy. Mode of birth was not associated with risk of food allergy and there was no evidence that nTreg at either six or twelve months were related to food allergy. The proportion of nTreg at birth is a major determinant of the proportion present throughout infancy, highlighting the importance of prenatal immune development. Exposure to the inflammatory stimulus of labour appears to reveal differences in immune function among infants at risk of food allergy. This article is protected by copyright. All rights reserved.",
keywords = "Food allergy, Na{\"i}ve regulatory T cells, Perinatal factors",
author = "F Collier and Ponsonby, {A L} and M O'Hely and Tang, {M L K} and R Saffery and J Molloy and Gray, {L E} and S Ranganathan and D Burgner and Allen, {Katrina J} and S Brix and P Vuillermin and {Investigator Group}, BIS",
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Collier, F, Ponsonby, AL, O'Hely, M, Tang, MLK, Saffery, R, Molloy, J, Gray, LE, Ranganathan, S, Burgner, D, Allen, KJ, Brix, S, Vuillermin, P & Investigator Group, BIS 2019, 'Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy', Allergy, vol. 74, no. 9, pp. 1760-1768. https://doi.org/10.1111/all.13822

Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy. / Collier, F; Ponsonby, A L; O'Hely, M; Tang, M L K; Saffery, R; Molloy, J; Gray, L E; Ranganathan, S; Burgner, D; Allen, Katrina J; Brix, S; Vuillermin, P; Investigator Group, BIS.

In: Allergy, Vol. 74, No. 9, 2019, p. 1760-1768.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy

AU - Collier, F

AU - Ponsonby, A L

AU - O'Hely, M

AU - Tang, M L K

AU - Saffery, R

AU - Molloy, J

AU - Gray, L E

AU - Ranganathan, S

AU - Burgner, D

AU - Allen, Katrina J

AU - Brix, S

AU - Vuillermin, P

AU - Investigator Group, BIS

PY - 2019

Y1 - 2019

N2 - In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequent allergic disease. However longitudinal studies, that account for relevant perinatal factors, are required. The aim of this study was to investigate the relationship between perinatal factors, naïve Treg (nTreg) over the first postnatal year, and development of food allergy. In a birth cohort (n=1074), the proportion of nTreg in the CD4+ T-cell compartment was measured by flow cytometry at birth (n=463), six (n=600) and twelve (n=675) months. IgE-mediated food allergy was determined by food challenge at one year. Associations between perinatal factors (gestation, labour, sex, birth size), nTreg at each time point and food allergy at 1 year were examined by linear regression. A higher proportion of nTreg at birth, larger birth size and male sex were each associated with higher nTreg in infancy. Exposure to labour, as compared to delivery by pre-labour Caesarean section, was associated with a transient decrease nTreg. Infants that developed food allergy had decreased nTreg at birth, and the labour-associated decrease in nTreg at birth was more evident among infants with subsequent food allergy. Mode of birth was not associated with risk of food allergy and there was no evidence that nTreg at either six or twelve months were related to food allergy. The proportion of nTreg at birth is a major determinant of the proportion present throughout infancy, highlighting the importance of prenatal immune development. Exposure to the inflammatory stimulus of labour appears to reveal differences in immune function among infants at risk of food allergy. This article is protected by copyright. All rights reserved.

AB - In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequent allergic disease. However longitudinal studies, that account for relevant perinatal factors, are required. The aim of this study was to investigate the relationship between perinatal factors, naïve Treg (nTreg) over the first postnatal year, and development of food allergy. In a birth cohort (n=1074), the proportion of nTreg in the CD4+ T-cell compartment was measured by flow cytometry at birth (n=463), six (n=600) and twelve (n=675) months. IgE-mediated food allergy was determined by food challenge at one year. Associations between perinatal factors (gestation, labour, sex, birth size), nTreg at each time point and food allergy at 1 year were examined by linear regression. A higher proportion of nTreg at birth, larger birth size and male sex were each associated with higher nTreg in infancy. Exposure to labour, as compared to delivery by pre-labour Caesarean section, was associated with a transient decrease nTreg. Infants that developed food allergy had decreased nTreg at birth, and the labour-associated decrease in nTreg at birth was more evident among infants with subsequent food allergy. Mode of birth was not associated with risk of food allergy and there was no evidence that nTreg at either six or twelve months were related to food allergy. The proportion of nTreg at birth is a major determinant of the proportion present throughout infancy, highlighting the importance of prenatal immune development. Exposure to the inflammatory stimulus of labour appears to reveal differences in immune function among infants at risk of food allergy. This article is protected by copyright. All rights reserved.

KW - Food allergy

KW - Naïve regulatory T cells

KW - Perinatal factors

U2 - 10.1111/all.13822

DO - 10.1111/all.13822

M3 - Journal article

VL - 74

SP - 1760

EP - 1768

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 9

ER -

Collier F, Ponsonby AL, O'Hely M, Tang MLK, Saffery R, Molloy J et al. Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy. Allergy. 2019;74(9):1760-1768. https://doi.org/10.1111/all.13822