N-Nitrosodiethanolamine Revisited

Jan Rud Andersen, Walther Batsberg Pedersen, Lars Carlsen, Helge Egsgaard, Elfinn Larsen, A. Senning

    Research output: Contribution to journalJournal articleResearch

    Abstract

    N-nitrosodiethanolamine is believed to be a weakly carcinogenic chemical, and as it occurs widely--in consumer products for example--it may constitute a significant hazard to humans. However, the chemical evidence concerning the identity, purity and properties of N-nitrosodiethanolamine is incomplete, and this casts some doubt on the basis of the current interest in this substance. In the present paper a purification procedure of synthetic N-nitrosodiethanolamine based on high-performance liquid chromatography is given. Other fractionation procedures such as gas liquid chromatography, ambient pressure column chromatography and distillation are shown to be inadequate. The purity and identity of purified N-nitrosodiethanolamine is established by means of electron impact and field ionization mass spectrometry, including metastable defocusing and collision induced decomposition techniques. Furthermore, 1H and 13C nuclear magnetic resonance and, to a lesser extent, infrared and ultraviolet spectroscopy are used. Deuterium labelled analogues of N-nitrosodiethanolamine and the parent diethanolamine are employed in rationalizing the results obtained.
    Original languageEnglish
    JournalBIOMEDICAL MASS SPECTROMETRY
    Volume7
    Issue number5
    Pages (from-to)205-210
    ISSN0306-042X
    Publication statusPublished - 1980

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