N-Glycosylation

Henrik Clausen (Inventor), Zhang Yang (Inventor), Adnan Fevzi Halim (Inventor), Eric Bennett (Inventor), Carsten Behrens (Inventor), Malene Bech Vester-Christensen (Inventor), Shamim Herbert Rahmann (Inventor)

Research output: Patent

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Abstract

The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

Original languageEnglish
IPCC12P 21/ 00 A I
Patent numberWO2016091268
Filing date16/06/2016
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date16/07/2015
Priority numberUS201562193403P
Publication statusPublished - 16 Jun 2016

Cite this

Clausen, H., Yang, Z., Fevzi Halim, A., Bennett, E., Behrens, C., Vester-Christensen, M. B., & Herbert Rahmann, S. (2016). IPC No. C12P 21/ 00 A I. N-Glycosylation. (Patent No. WO2016091268).