N-Glycosylation

Henrik Clausen; Zhang Yang; Adnan  Fevzi Halim; Eric Bennett; Carsten Behrens; Malene Bech Vester-Christensen; Shamim  Herbert Rahmann

N-Glycosylation

Henrik Clausen (Inventor), Zhang Yang (Inventor), Adnan Fevzi Halim (Inventor), Eric Bennett (Inventor), Carsten Behrens (Inventor), Malene Bech Vester-Christensen (Inventor), Shamim Herbert Rahmann (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

Original language	English
IPC	C12P 21/ 00 A I
Patent number	WO2016091268
Filing date	16/06/2016
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	16/07/2015
Priority number	US201562193403P
Publication status	Published - 16 Jun 2016

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abstract = "The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.",

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T1 - N-Glycosylation

AU - Clausen, Henrik

AU - Yang, Zhang

AU - Fevzi Halim, Adnan

AU - Bennett, Eric

AU - Behrens, Carsten

AU - Vester-Christensen, Malene Bech

AU - Herbert Rahmann, Shamim

PY - 2016/6/16

Y1 - 2016/6/16

N2 - The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

AB - The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

M3 - Patent

M1 - WO2016091268

Y2 - 2016/06/16

ER -

N-Glycosylation

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